Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,670.00 | |
50 mg | 6-8 weeks | $ 2,180.00 | |
100 mg | 6-8 weeks | $ 2,800.00 |
Description | CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis. |
Targets&IC50 | c-Kit:75 nM , PDGFRβ:80 nM , DDR2:325 nM , BLK:81 nM , DDR1:116 nM , CSF1R:227 nM , Abl (type II):46 nM , Lck:12 nM |
In vitro | CHMFL-ABL/KIT-155 also presents significant inhibitory activities to BLK, CSF1R, DDR1, DDR2, LCK and PDGFRβ (IC50s: 81 nM, 227 nM, 116 nM, 325 nM,12 nM, and 80 nM) kinases. CHMFL-ABL/KIT-155 exhibits anti-proliferation activities in the BCR-ABL dependent CML cancer cell lines such as MEG-01 (GI50: 0.02 μM), K562 (GI50: 0.027 μM), and KU812 (GI50: 0.056 μM). It also potently inhibits the growth of c-KIT dependent GISTs cancer cell lines including GIST-882 (GI50: 0.095 μM), GIST-T1 (GI50: 0.023 μM) but not c-KIT independent GIST-48B (GI50: 3.96 μM). |
In vivo | In female nu/nu mice bearing established K562 tumor xenografts, CHMFL-ABL/KIT-155 (25-100 mg/kg; p.o.; once daily for 28 days) shows dose-dependent tumor progression suppression without apparent toxicity. |
Synonyms | CHMFL-ABL-KIT-155 |
Molecular Weight | 609.68 |
Formula | C33H38F3N5O3 |
CAS No. | 2081093-21-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CHMFL-ABL/KIT-155 2081093-21-0 Tyrosine Kinase/Adaptors c-Kit CHMFL-ABL-KIT-155 CHMFL ABL/KIT 155 CHMFL-ABL-KIT 155 CHMFL-ABL-KIT155 CHMFL-ABL/KIT155 CHMFLABL/KIT155 CHMFL-ABL/KIT 155 inhibitor inhibit