Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
2 mg | In stock | $ 56.00 | |
5 mg | In stock | $ 92.00 | |
10 mg | In stock | $ 145.00 | |
25 mg | In stock | $ 246.00 | |
50 mg | In stock | $ 363.00 | |
100 mg | In stock | $ 539.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 109.00 |
Description | CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast. |
Targets&IC50 | GPR55:0.15 μM |
In vitro | In yeast cells expressing human GPR55, CID16020046 inhibited agonist-induced receptor activation. In human embryonic kidney (HEK293) cells stably expressing human GPR55, CID16020046 behaved as an antagonist on LPI-mediated Ca2+ release and extracellular signal-regulated kinases activation, but not in HEK293 cells expressing cannabinoid receptor 1 or 2 (CB1 or CB2). CID16020046 dose-dependently inhibited lysophosphatidylinositol (LPI)-induced activation of nuclear factor of activated T-cells (NFAT), nuclear factor κ of activated B cells (NF-κB) and serum response element, translocation of NFAT and NF-κB, and GPR55 internalization [1]. |
Synonyms | C390-0219 |
Molecular Weight | 425.44 |
Formula | C25H19N3O4 |
CAS No. | 834903-43-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL
You can also refer to dose conversion for different animals. More
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CID 16020046 834903-43-4 GPCR/G Protein Cannabinoid Receptor cells wound Ca2+ inhibit ERK1/2 GPR55 hERG acetylcholinesterase HEK function phosphorylation KCNH2 LPI healing endothelial platelet Inhibitor HMVEC lysophosphatidylinositol C390-0219 m-opioid G protein-coupled receptor 55 CID16020046 CID-16020046 inhibitor