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CP 376395

Catalog No. T4329 CAS 175140-00-8

Synonyms: CP-316311

CP 376395 (CP-316311) is an effective and specific Corticotropin-releasing factor 1 (CRF1) receptor antagonist.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CP 376395, CAS 175140-00-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 35.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 105.00
10 mg	In stock	$ 193.00
25 mg	In stock	$ 405.00
50 mg	In stock	$ 590.00
100 mg	In stock	$ 859.00
500 mg	In stock	$ 1,750.00
1 mL * 10 mM (in DMSO)	In stock	$ 106.00

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Purity: 99.96%

Purity: 99.83%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CP 376395 (CP-316311) is an effective and specific Corticotropin-releasing factor 1 (CRF1) receptor antagonist.
In vitro	It is highly selective for the human CRF1 receptor subtype,and exhibits affinities against 40 neurotransmitter receptor and ion channels(>1 μM).
In vivo	Pretreatment with CP 376395 (ID50=17.8 mg/kg, p.o.) reverses the excitation of locus coeruleus neurons induced by icv CRF (3 μg) completely blocked the enhanced startle response, while pretreatment with CP 376395(10 mg/kg, p.o.) induced by icv CRF (1 μg) is partially blocked.
Kinase Assay	In supernatants from cells, which are incubated in OSS_128167 (100 μM) for 18 hours,TNF-a levels are measured .
Animal Research	Beagle dogs weighing between 8 and 15 kg are administered with CP 376395 hydrochloride salt (1.0 mg/kg) into the cephalic vein of the foreleg. Beagle dogs are treated with CP 376395(10 mg/mL) prepared in 0.1% methyl cellulose at pH 2 by oral.

Synonyms	CP-316311
Molecular Weight	326.48
Formula	C21H30N2O
CAS No.	175140-00-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 100 mg/mL (306.30 mM)

References and Literature

1. Chen YL, et al. 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library GPCR Compound Library ReFRAME Related Library Bioactive Compounds Library Max NO PAINS Compound Library Antidepressant Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CP 376395 175140-00-8 GPCR/G Protein CRFR inhibit CP 316311 CP-376395 CP316311 Inhibitor Corticotropin-releasing Factor Receptor CP376395 CP-316311 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.