Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 44.00 |
Description | CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy. |
Targets&IC50 | VEGFR2:11 nM, FGFR:9 nM |
In vitro | CP-547632 hydrochloride (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion (IC50: 6 nM). |
In vivo | In DLD-1, Colo-205, and MDA-MB-231 xenografts, CP-547632 hydrochloride (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth. CP-547632 hydrochloride (oral; 50 mg/kg) yields plasma concentrations above 500 ng/ml for 12 hours. |
Molecular Weight | 568.86 |
Formula | C20H25BrClF2N5O3S |
CAS No. | 252003-71-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 38.33 mg/mL (67.38 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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CP-547632 hydrochloride 252003-71-7 Angiogenesis Tyrosine Kinase/Adaptors FGFR CP 547632 hydrochloride CP547632 hydrochloride CP547632 Hydrochloride CP 547632 Hydrochloride CP-547632 Hydrochloride inhibitor inhibit