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CPI-1205

Catalog No. T8510 CAS 1621862-70-1

Synonyms: Lirametostat

CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 μM, EC50 : 0.032 μM) .

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CPI-1205, CAS 1621862-70-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 85.00
2 mg	In stock	$ 123.00
5 mg	In stock	$ 223.00
10 mg	In stock	$ 328.00
25 mg	In stock	$ 556.00
50 mg	In stock	$ 783.00
1 mL * 10 mM (in DMSO)	In stock	$ 473.00

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Purity: 99.7%

Purity: 98.71%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 μM, EC50 : 0.032 μM) .
Targets&IC50	EZH2:0.002 μM
In vivo	CPI-1205 is a highly potent (biochemical IC50 = 0.002 μM, cellular EC50 = 0.032 μM) and selective inhibitor of EZH2.?This compound demonstrates robust antitumor effects in a Karpas-422 xenograft model when dosed at 160 mg/kg BID.

Synonyms	Lirametostat
Molecular Weight	518.57
Formula	C27H33F3N4O3
CAS No.	1621862-70-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/ml(183.19 mM)

References and Literature

1. Vaswani RG, et al. Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas. J Med Chem. 2016 Nov 10;59(21):9928-9941. 2. Gulati N , Béguelin, Wendy, Giulino-Roth L . Enhancer of zeste homolog 2 (EZH2) inhibitors[J]. Leukemia & Lymphoma, 2018:1-12.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library ReFRAME Related Library Bioactive Compound Library Bioactive Compounds Library Max Apoptosis Compound Library Epigenetics Compound Library Chromatin Modification Compound Library NO PAINS Compound Library Anti-Aging Compound Library Histone Modification Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CPI-1205 1621862-70-1 Chromatin/Epigenetic Histone Methyltransferase CPI1205 Lirametostat CPI 1205 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.