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CPI-203

Catalog No. T6026 CAS 1446144-04-2

Synonyms: CPI 203, CPI203

CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).

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CPI-203, CAS 1446144-04-2

Pack Size	Availability	Price/USD
2 mg	In stock	$ 60.00
5 mg	In stock	$ 108.00
10 mg	In stock	$ 172.00
25 mg	In stock	$ 369.00
50 mg	In stock	$ 554.00
1 mL * 10 mM (in DMSO)	In stock	$ 94.00

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Purity: 99.66%

Purity: 99.01%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
Targets&IC50	BRD4:37 nM
In vitro	CPI203 inhibits BRD4 in vitro and in cells, while does not affect BRD4 kinase activity in vitro. [1] CPI203 exerts a cytostatic effect in all the 9 MCL cell lines analyzed with GI50 ranging from 0.06 to 0.71 μM, with low cytotoxicity in normal PBMCs from healthy donors. Furthermore, lenalidomide and CPI203, by targeting IRF4 and MYC, efficiently activates the cell death program in MCL cells resistant to bortezomib. [2]
Kinase Assay	BRD4 α-screen assay: The BRD4 α-screen assay is a proximity-based assay using a tetraacteylated H4 peptide and the isolated bromodomain 1 of human BRD4. IC50 values are calculated using a 10-point serial dilution of BET inhibitor.

Synonyms	CPI 203, CPI203
Molecular Weight	399.9
Formula	C19H18ClN5OS
CAS No.	1446144-04-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 72 mg/mL(180 mM)

References and Literature

1. Devaiah BN, et al. Proc Natl Acad Sci U S A. 2012, 109(18), 6927-6932.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library NO PAINS Compound Library Target-Focused Phenotypic Screening Library Bioactive Compound Library Kinase Inhibitor Library Chromatin Modification Compound Library Apoptosis Compound Library PPI Inhibitor Library Histone Modification Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CPI-203 1446144-04-2 Apoptosis Chromatin/Epigenetic Epigenetic Reader Domain Inhibitor inhibit CPI 203 CPI203 inhibitor

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