Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base (CS-003) has therapeutic effects on neurokinin-related respiratory diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 2,570.00 | |
50 mg | 10-14 weeks | $ 3,380.00 | |
100 mg | 10-14 weeks | $ 4,600.00 |
Description | CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base (CS-003) has therapeutic effects on neurokinin-related respiratory diseases. |
Targets&IC50 | NK1:2.3 nM (ki), NK2:0.54 nM (ki), NK3:0.74 nM (ki) |
In vitro | CS-003 (0.01-10 μM; 24 hours) inhibited inositol phosphate formation induced by NK1, NK2 or NK3 in a concentration-dependent manner, with pA2 values of 8.7, 9.4 and 9.5 μM, respectively. |
In vivo | CS-003 (intravenous injection; 0.01-3.0 mg / kg; neurokinin A / B / C 5 minutes before injection) inhibits substance P-induced increase in tracheal vascular permeability, induced by neurokinin A and neurokinin B The bronchi contracted and the ID50 values were 0.13, 0.040 and 0.063 mg / kg, respectively. |
Molecular Weight | 673.65 |
Formula | C34H38Cl2N2O6S |
CAS No. | 191672-52-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CS-003 Free base 191672-52-3 GPCR/G Protein Neuroscience Neurokinin receptor CS 003 CS 003 Free base CS003 Free base CS003 CS-003 inhibitor inhibit