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CWP232228

Catalog No. T10904 CAS 1144044-02-9

CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting the growth of breast cancer and liver cancer stem cells (CSC) without toxicity.

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CWP232228, CAS 1144044-02-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 233.00
5 mg	In stock	$ 497.00
10 mg	In stock	$ 723.00
25 mg	In stock	$ 1,130.00
50 mg	In stock	$ 1,520.00
100 mg	In stock	$ 1,980.00

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Purity: 96.13%

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Description	CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting the growth of breast cancer and liver cancer stem cells (CSC) without toxicity.
In vitro	CWP232228 (0.01-100 μM; 48 hours) inhibited cell proliferation, and IC50 values in mouse (4T1) and human (MDA-MB-435) breast cancer cell lines were 2 and 0.8 μM, respectively. CWP232228 (0.01-10 μM; 48 hours) inhibited cell proliferation in Hep3B, Huh7 and HepG2 cells with IC50 of 2.566, 2.630 and 2.596 μM, respectively.
In vivo	CWP232228 (100 mg/kg, administered i.p.; daily; mice with 4T1 cell tumors for 21 days; mice with MDA-MB-435 cell tumors for 60 days) resulted in a significant reduction in tumor volume.

Molecular Weight	673.66
Formula	C33H36N7O7P
CAS No.	1144044-02-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 60 mg/mL (83.61 mM), Sonication is recommended.

References and Literature

1. Jang GB, et al. Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells. Cancer Res. 2015 Apr 15;75(8):1691-702. 2. Kim JY, et al. Oncotarget. 2016 Apr 12;7(15):20395-409. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Osteogenesis Compound Library Stem Cell Differentiation Compound Library NO PAINS Compound Library Anti-Obesity Compound Library Anti-Ovarian Cancer Compound Library Anti-Breast Cancer Compound Library Reprogramming Compound Library Bioactive Compounds Library Max

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Keywords

CWP232228 1144044-02-9 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin CWP 232228 Beta catenin Wnt CWP-232228 Breast β-catenin Inhibitor cells signaling stem Cancer inhibit liver inhibitor

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