Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CYP11B2-IN-1 is an effective and selective inhibitor of CYP11B2 with IC50s of 2.3 nM and 142 nM for CYP11B2 and CYP11B1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
2 mg | In stock | $ 131.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 313.00 | |
25 mg | In stock | $ 533.00 | |
50 mg | In stock | $ 768.00 | |
100 mg | In stock | $ 1,080.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 226.00 |
Description | CYP11B2-IN-1 is an effective and selective inhibitor of CYP11B2 with IC50s of 2.3 nM and 142 nM for CYP11B2 and CYP11B1. |
Targets&IC50 | CYP11B2:2.3 nM, CYP11B1:142 nM |
In vitro | The IC50 of CYP11B2-IN-1 for CYP19 is 1021 nM[1]. |
In vivo | CYP11B2-IN-1 dose-dependently produces aldosterone lowering efficacy without affecting cortisol levels in rhesus pharmacodynamic models. CYP11B2-IN-1 (0.01 and 0.3 mg/kg; i.v.) reduces aldosterone AUC of 62% and 95%, respectively[1]. |
Molecular Weight | 311.35 |
Formula | C18H18FN3O |
CAS No. | 1356479-78-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (160.59 mM)
You can also refer to dose conversion for different animals. More
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CYP11B2-IN-1 1356479-78-1 Metabolism P450 CYP11B2 IN 1 CYP-11B2-IN-1 CYP11B2IN1 inhibitor inhibit