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Canertinib dihydrochloride

Catalog No. T2501 CAS 289499-45-2

Synonyms: CI-1033 dihydrochloride, PD-183805 dihydrochloride, Canertinib

Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities.

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Canertinib dihydrochloride Chemical Structure

Canertinib dihydrochloride, CAS 289499-45-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 32.00
10 mg	In stock	$ 48.00
50 mg	In stock	$ 68.00
1 mL * 10 mM (in DMSO)	In stock	$ 47.00

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Purity: 99.23%

Biological Description

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Storage & Solubility Information

Description	Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities.
Targets&IC50	EGFR:7.4nM, ErbB2:9 nM
Kinase Assay	Kinase inhibition: Cediranib is dissolved in DMSO at a concentration of 10 mM. All enzyme assays are run at, or just below, the respective Km for ATP (0.2 - 30 μM). The inhibitory activity of Cediranib is determined against a range of recombinant tyrosine kinases [KDR, Flt-1, Flt-4, c-Kit, PDGFRα, PDGFRβ, CSF-1R, Flt-3, FGFR1, Src, Abl, epidermal growth factor receptor (EGFR), ErbB2, Aurora A, and Aurora B] using ELISA. Selectivity versus CDK2 and CDK4 serine/threonine kinases is examined using scintillation proximity assays with a retinoblastoma substrate and [γ-sup>33P]ATP. Activity of Cediranib is compared to MAPK kinase (MEK), which shows dual specificity. It is determined using a MAPK substrate, [γ-33P]ATP, and paper capture/scintillation counting.

Synonyms	CI-1033 dihydrochloride, PD-183805 dihydrochloride, Canertinib
Molecular Weight	558.86
Formula	C24H27Cl3FN5O3
CAS No.	289499-45-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55.9 mg/mL(100 mM)

References and Literature

1. Smaill JB et al. J Med Chem. 2000; 43(7): 1380-1397.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Inhibitor Library Kinase Inhibitor Library Anti-Cancer Drug Library Covalent Inhibitor Library Clinical Compound Library Immuno-Oncology Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Canertinib dihydrochloride 289499-45-2 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR ErbB-1 PD 183805 CI-1033 dihydrochloride PD 183805 Dihydrochloride PD-183805 dihydrochloride Orthopoxvirus PD-183805 CI 1033 Dihydrochloride PD183805 Dihydrochloride PD183805 CI1033 Dihydrochloride Epidermal growth factor receptor CI 1033 PD-183805 Dihydrochloride Inhibitor CI1033 Canertinib inhibit HER1 CI-1033 Canertinib Dihydrochloride CI-1033 Dihydrochloride inhibitor

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