Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 45.00 | |
10 mg | In stock | $ 63.00 | |
25 mg | In stock | $ 117.00 | |
50 mg | In stock | $ 186.00 | |
100 mg | In stock | $ 297.00 | |
500 mg | In stock | $ 622.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 75.00 |
Description | Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity. |
In vitro | Capmatinib was found to be highly selective for MET over other kinases.?It was active against cancer models that are characterized by MET amplification, marked MET overexpression, MET exon 14 skipping mutations, or MET activation via expression of the ligand hepatocyte growth factor (HGF)[1]. |
In vivo | In cancer models where MET is the dominant oncogenic driver, anticancer activity could be further enhanced by combination treatments, for example, by the addition of apoptosis-inducing BH3 mimetics.?The combinations of capmatinib and other kinase inhibitors resulted in enhanced anticancer activity against models where MET activation co-occurred with other oncogenic drivers, for example EGFR activating mutations[1]. |
Synonyms | INCB28060 2HCl.H2O, INC-280 2HCl.H2O, NVP-INC280 2HCl.H2O |
Molecular Weight | 503.36 |
Formula | C23H21Cl2FN6O2 |
CAS No. | 1865733-40-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (59.6 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Capmatinib 2HCl.H2O 1865733-40-9 Tyrosine Kinase/Adaptors c-Met/HGFR S114 SNU-5 ATP competitive Balb/c nu/nu mice U-87MG INCB-28060 dihydrochloride INCB28060 2HCl.H2O orally active Capmatinib dihydrochloride Capmatinib 2HCl.H-2O INC-280 2HCl.H2O INC280 dihydrochloride Apoptosis NVP-INC280 2HCl.H2O inhibit Inhibitor H441 inhibitor