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Captopril

Catalog No. T1462   CAS 62571-86-2
Synonyms: SQ 14225, SQ-14534, SA333

Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure.

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Captopril Chemical Structure
Captopril, CAS 62571-86-2
Pack Size Availability Price/USD Quantity
50 mg In stock $ 40.00
100 mg In stock $ 48.00
200 mg In stock $ 59.00
500 mg In stock $ 81.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.88%
Purity: 99.54%
Purity: 98.79%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure.
Targets&IC50 ACE:6 nM
Kinase Assay Binding assay: Cells are plated in 24-well plates and cultured until confluence. Before the experiment, the cells are washed three times with 0.5 mL per well of DMEM at room temperature. After removal of the medium, 400 μL binding DMEM is added and the plate is then left for 15 min at 37 ℃. For saturation binding assays cells are incubated with increasing concentrations [3H]Candesartan (final concentrations between 0.15 nM and 15 nM) in a final volume of 0.5 mL at 37 ℃ for 5 min to 180 min. For competition binding assays 50 μL of buffer or 50 μL of buffer containing increasing concentrations of unlabelled Candesartan is added. After 30 min, 50 μL of buffer containing [3H]Candesartan (final concentration 1.1 nM) or [3H]Candesartan (final concentration 1.0 nM) is added, and the cells are further incubated for 30 min at 37 ℃.
Synonyms SQ 14225, SQ-14534, SA333
Molecular Weight 217.29
Formula C9H15NO3S
CAS No. 62571-86-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 21.7 mg/mL (100 mM)

DMSO: 21.7 mg/mL (100 mM)

TargetMolReferences and Literature

1. Andujar-Sanchez M, et al. FEBS Lett. 2007 Jul 24;581(18):3449-54.

TargetMolCitations

1. Cheng S, Jin P, Li H, et al. Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model. Frontiers in Pharmacology. 2021: 2866. 2. Yang M, Wu H, Qian H, et al.Linggui Zhugan decoction delays ventricular remodeling in rats with chronic heart failure after myocardial infarction through the Wnt/β-catenin signaling pathway.Phytomedicine.2023: 155026.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Angiogenesis related Compound Library Drug-Fragment Library Bioactive Compounds Library Max Anti-Metabolism Disease Compound Library FDA-Approved Drug Library Anti-Cardiovascular Disease Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets
Angiotensin II (3-8), human TFA Cilazapril Monohydrate Pomisartan 2HCl Ramipril Zofenopril calcium Olmesartan Angiotensin 1/2 (5-7) acetate TRV055 acetate

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Keywords

Captopril 62571-86-2 Endocrinology/Hormones RAAS antihypertensive Angiotensin-converting Enzyme (ACE) SQ 14225 failure SQ 14534 inhibit oral SQ14534 congestive hypertension SQ-14534 Inhibitor SA 333 SQ14225 SQ-14225 SA-333 heart SA333 inhibitor

 

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