Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 40.00 | |
100 mg | In stock | $ 48.00 | |
200 mg | In stock | $ 59.00 | |
500 mg | In stock | $ 81.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure. |
Targets&IC50 | ACE:6 nM |
Kinase Assay | Binding assay: Cells are plated in 24-well plates and cultured until confluence. Before the experiment, the cells are washed three times with 0.5 mL per well of DMEM at room temperature. After removal of the medium, 400 μL binding DMEM is added and the plate is then left for 15 min at 37 ℃. For saturation binding assays cells are incubated with increasing concentrations [3H]Candesartan (final concentrations between 0.15 nM and 15 nM) in a final volume of 0.5 mL at 37 ℃ for 5 min to 180 min. For competition binding assays 50 μL of buffer or 50 μL of buffer containing increasing concentrations of unlabelled Candesartan is added. After 30 min, 50 μL of buffer containing [3H]Candesartan (final concentration 1.1 nM) or [3H]Candesartan (final concentration 1.0 nM) is added, and the cells are further incubated for 30 min at 37 ℃. |
Synonyms | SQ 14225, SQ-14534, SA333 |
Molecular Weight | 217.29 |
Formula | C9H15NO3S |
CAS No. | 62571-86-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 21.7 mg/mL (100 mM)
DMSO: 21.7 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Captopril 62571-86-2 Endocrinology/Hormones RAAS antihypertensive Angiotensin-converting Enzyme (ACE) SQ 14225 failure SQ 14534 inhibit oral SQ14534 congestive hypertension SQ-14534 Inhibitor SA 333 SQ14225 SQ-14225 SA-333 heart SA333 inhibitor