Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 34.00 | |
100 mg | In stock | $ 48.00 | |
200 mg | In stock | $ 59.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 30.00 |
Description | Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy. |
Targets&IC50 | AC:29 ± 5 nM |
In vitro | Carmofur is one of the masked compounds of 5-FU, which was modified for more potent antineoplastic activity and less toxicity. Carmofur is converted in vivo into 5-FU directly or via intermetabolites, such as 1-(carboxypentylcarbamoyl)-5-fluorouracil and/or 1-(carboxypropylcarbomoyl)-5-fluorouraci. Carmofur and its metabolites gradually accumulate in the brain during continuous administration and are removed very slowly. Carmofur has potent neurotoxicity which can produce severe leucoencephalopathy resembling methotrexate leucoencephalopathy both clinically and on brain CT, together with a cerebellar syndrome similar to that following 5-FU neurotoxicity. [1] |
Synonyms | HCFU |
Molecular Weight | 257.26 |
Formula | C11H16FN3O3 |
CAS No. | 61422-45-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49 mg/mL (190.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 10 mg/mL (38.87 mM)
You can also refer to dose conversion for different animals. More
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Carmofur 61422-45-5 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology SARS-CoV Virus Protease Nucleoside Antimetabolite/Analog DNA/RNA Synthesis antineoplastic SARS coronavirus inhibit derivative protease HCFU Inhibitor Mpro 5-fluorouracil inhibitor