keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent, selective inhibitor of carnosinase 1 (CN1), exhibiting a K_i of 11 nM against human recombinant CN1. This compound shows promise for the treatment of diabetic nephropathy (DN) [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | 10-14 weeks | $ 1,240.00 |
Description | Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent, selective inhibitor of carnosinase 1 (CN1), exhibiting a K_i of 11 nM against human recombinant CN1. This compound shows promise for the treatment of diabetic nephropathy (DN) [1]. |
Targets&IC50 | CN1 (human):ki: 11 nM |
In vitro | Carnostatine inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. At a carnosine concentration of 200 μM, Carnostatine has an IC 50 value of 18 nM on human recombinant CN1, i.e., close to the K m of 190 μM [1]. |
In vivo | Subcutaneous administration of 30 mg/kg Carnostatine (SAN9812) results in a sustained reduction in circulating CN1 activity in human CN1 transgenic (TG) mice. Simultaneous administration of Carnosine and Carnostatine increases carnosine levels in plasma and kidney by up to 100-fold compared to treatment-na ve CN1-overexpressing mice [1]. Animal Model: Human carnosinase (CNDP1) transgenic mice on a BTBR wt/ob background [1] Dosage: 3 mg/kg i.v. or 30 mg/kg s.c. (Pharmacokinetic Analysis) Administration: Single bolus administration Result: Subcutaneous administration of 30 mg/kg led to a sustained reduction in circulating CN1 activity. |
Synonyms | SAN9812 hydrochloride |
Molecular Weight | 292.72 |
Formula | C10H17ClN4O4 |
CAS No. | T10684L |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 250 mg/mL (854.06 mM)
You can also refer to dose conversion for different animals. More
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Carnostatine hydrochloride T10684L Others SAN 9812 Hydrochloride Carnostatine Hydrochloride SAN9812 Hydrochloride SAN-9812 Hydrochloride SAN9812 hydrochloride inhibitor inhibit