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Carprofen

Catalog No. T1325   CAS 53716-49-7
Synonyms: Ridamyl, Imadyl, Rimadyl

Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.

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Carprofen Chemical Structure
Carprofen, CAS 53716-49-7
Pack Size Availability Price/USD Quantity
50 mg In stock $ 36.00
100 mg In stock $ 52.00
200 mg In stock $ 75.00
500 mg In stock $ 125.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.65%
Purity: 99.45%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.
Targets&IC50 canine COX2:30 nM
In vitro Administration of 4 mg/kg Carprofen significantly elevated peak plasma concentrations in dogs. Compared to buprenorphine, Carprofen treatment resulted in marginally superior analgesic effects with reduced sedative action in canines. Preoperative administration of Carprofen in dogs yielded lower pain scores than other groups, with marked effectiveness observed 2 hours post-extubation. Carprofen provided sustained analgesia for 18 hours in treated canines without adverse side effects and notably improved the speed of recovery in limping birds.
In vivo Carprofen binds to human serum albumin (HSA) via fluorescence and equilibrium dialysis methods, with two sets of binding constants [K1=5.1 μM (fluorescence) and 3.7 μM (ED), K2=37 μM (fluorescence) and 13 μM (ED)]. It predominantly binds to site II, the benzodiazepine site, while site I, the Warfarin site, exhibits a lower affinity for Carprofen. The carboxyl group of Carprofen plays a significant role in its high-affinity binding with HSA. Additionally, Carprofen (S and R enantiomers) inhibits canine COX2 with an IC50 of 0.102 microM, primarily attributed to the S enantiomer (IC50, 0.0371 μM), which is approximately 200 times more potent than the R enantiomer (IC50, 5.97 microM).
Synonyms Ridamyl, Imadyl, Rimadyl
Molecular Weight 273.71
Formula C15H12ClNO2
CAS No. 53716-49-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 51 mg/mL (186.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 51 mg/mL (186.3 mM)

TargetMolReferences and Literature

1. Ricketts AP, et al. Am J Vet Res, 1998, 59(11), 1441-1446. 2. Rahman MH, et al. Biochem Pharmacol, 1993, 46(10), 1721-1731. 3. Lascelles BD, et al. Vet Surg, 1998, 27(6), 568-582. 4. Lascelles BD, et al. Vet Rec, 1994, 134(8), 187-191. 5. McGeown D, et al. Vet Rec, 1999, 144(24), 668-671.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Highly Selective Inhibitor Library Anti-Cardiovascular Disease Compound Library Anti-Fibrosis Compound Library Lipid Metabolism Compound Library Pyroptosis Compound Library Anti-Cancer Compound Library Neuronal Signaling Compound Library Anti-Obesity Compound Library

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Keywords

Carprofen 53716-49-7 Autophagy Immunology/Inflammation Metabolism Neuroscience FAAH COX Inhibitor Cyclooxygenase Fatty acid amide hydrolase inhibit Ridamyl Imadyl Rimadyl inhibitor

 

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