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Cefditoren pivoxil

Catalog No. T1405   CAS 117467-28-4
Synonyms: ME 1207, Cefditoren pivaloyloxymethyl ester, Cefditoren pivoxyl

Cefditoren pivoxil (ME 1207) is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity.

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Cefditoren pivoxil Chemical Structure
Cefditoren pivoxil, CAS 117467-28-4
Pack Size Availability Price/USD Quantity
10 mg In stock $ 54.00
25 mg In stock $ 108.00
50 mg In stock $ 143.00
100 mg In stock $ 198.00
200 mg In stock $ 243.00
500 mg In stock $ 397.00
1 mL * 10 mM (in DMSO) In stock $ 60.00
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Purity: 97.3%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Cefditoren pivoxil (ME 1207) is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity.
In vitro Cefditoren has MIC50/MIC90 results for Moraxella catarrhalis and Haemophilus influenzae of 0.12/0.5 and < or = 0.008/0.015 mg/mL, respectively. [1] Cefditoren (MIC(90), 0.5 mg/mL) is 4- to 128-fold more active than comparison beta-lactams against the pneumoococci and was the most potent beta-lactam (including penicillin) versus beta-haemolytic streptococci. Cefditoren (MIC(90) in mg/mL/% susceptible) activity against all tested H. influenzae (0.03/100) and M. catarrhalis (0.06-0.5/100) is comparable to Cefixime and significantly greater than cefaclor. Cefditoren pharmacokinetics demonstrate a T(1/2) of 1.5-2 hours and C(max) values of 2.8 and 4.6 mg/mL, respectively with 200 or 400 mg doses of Cefditoren pivoxil. [2] Cefditoren possesses a broad-spectrum of cidal antibacterial activity against both Gram-positive and Gram-negative species with stability to many beta-lactamases of clinical importance. [3] Cefditoren is also effective against methicillin-susceptible strains of Staphylococcus aureus. Cefditoren has compared favorably against other orally administered antibiotics used against the most commonly isolated respiratory tract pathogens. [4] Cefditoren up-regulates the expression levels of Mrp2, Bcrp and Oat2, and down-regulate P-gp and Oct1 mRNA expression. [5]
Synonyms ME 1207, Cefditoren pivaloyloxymethyl ester, Cefditoren pivoxyl
Molecular Weight 620.72
Formula C25H28N6O7S3
CAS No. 117467-28-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 100 mg/mL (161.1 mM)

TargetMolReferences and Literature

1. Jones RN, et al. Diagn Microbiol Infect Dis, 1998, 31(4), 573-578. 2. Johnson DM, et al. Diagn Microbiol Infect Dis, 2000, 37(2), 99-105. 3. Felmingham D, et al. Drugs Exp Clin Res, 1994, 20(4), 127-147. 4. Balbisi EA, et al. Pharmacotherapy, 2002, 22(10), 1278-1293. 5. Meng Q, et al. Drug Metab Pharmacokinet, 2010, 25(4), 320-327.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max FDA-Approved Drug Library NO PAINS Compound Library Approved Drug Library Nonsteroidal Anti-Inflammatory Compound Library Drug-induced Liver Injury (DILI) Compound Library Clinical Compound Library Human Metabolite Library Anti-Bacterial Compound Library Drug Repurposing Compound Library

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Keywords

Cefditoren pivoxil 117467-28-4 Microbiology/Virology Antibacterial Antibiotic ME 1207 Cefditoren pivaloyloxymethyl ester Cefditoren pivoxyl ME-1207 ME1207 inhibitor inhibit

 

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