Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cefditoren pivoxil (ME 1207) is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 54.00 | |
25 mg | In stock | $ 108.00 | |
50 mg | In stock | $ 143.00 | |
100 mg | In stock | $ 198.00 | |
200 mg | In stock | $ 243.00 | |
500 mg | In stock | $ 397.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 60.00 |
Description | Cefditoren pivoxil (ME 1207) is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. |
In vitro | Cefditoren has MIC50/MIC90 results for Moraxella catarrhalis and Haemophilus influenzae of 0.12/0.5 and < or = 0.008/0.015 mg/mL, respectively. [1] Cefditoren (MIC(90), 0.5 mg/mL) is 4- to 128-fold more active than comparison beta-lactams against the pneumoococci and was the most potent beta-lactam (including penicillin) versus beta-haemolytic streptococci. Cefditoren (MIC(90) in mg/mL/% susceptible) activity against all tested H. influenzae (0.03/100) and M. catarrhalis (0.06-0.5/100) is comparable to Cefixime and significantly greater than cefaclor. Cefditoren pharmacokinetics demonstrate a T(1/2) of 1.5-2 hours and C(max) values of 2.8 and 4.6 mg/mL, respectively with 200 or 400 mg doses of Cefditoren pivoxil. [2] Cefditoren possesses a broad-spectrum of cidal antibacterial activity against both Gram-positive and Gram-negative species with stability to many beta-lactamases of clinical importance. [3] Cefditoren is also effective against methicillin-susceptible strains of Staphylococcus aureus. Cefditoren has compared favorably against other orally administered antibiotics used against the most commonly isolated respiratory tract pathogens. [4] Cefditoren up-regulates the expression levels of Mrp2, Bcrp and Oat2, and down-regulate P-gp and Oct1 mRNA expression. [5] |
Synonyms | ME 1207, Cefditoren pivaloyloxymethyl ester, Cefditoren pivoxyl |
Molecular Weight | 620.72 |
Formula | C25H28N6O7S3 |
CAS No. | 117467-28-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 100 mg/mL (161.1 mM)
You can also refer to dose conversion for different animals. More
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Cefditoren pivoxil 117467-28-4 Microbiology/Virology Antibacterial Antibiotic ME 1207 Cefditoren pivaloyloxymethyl ester Cefditoren pivoxyl ME-1207 ME1207 inhibitor inhibit