Home Tools

Ceftiofur hydrochloride

Catalog No. T6268 CAS 103980-44-5

Synonyms: Ceftiofur HCl, U-67279A, Excenel hydrochloride

Ceftiofur hydrochloride (U-67279A) is the hydrochloride salt form of ceftiofur, a semisynthetic, beta-lactamase-stable, broad-spectrum, third-generation cephalosporin with antibacterial activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ceftiofur hydrochloride Chemical Structure

Ceftiofur hydrochloride, CAS 103980-44-5

Pack Size	Availability	Price/USD
100 mg	In stock	$ 34.00
200 mg	In stock	$ 42.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

Bulk Inquiry

Select Batch

Purity: 99.51%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ceftiofur hydrochloride (U-67279A) is the hydrochloride salt form of ceftiofur, a semisynthetic, beta-lactamase-stable, broad-spectrum, third-generation cephalosporin with antibacterial activity.
In vitro	Ceftiofur can downregulate tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), but did not affect interleukin-10 (IL-10) production. Ceftiofur significantly inhibits extracellular signal-regulated kinase (ERK), p38, and c-jun NH(2)-terminal kinase (JNK) phosphorylation protein expression in RAW 264.7 cells. Ceftiofur also inhibits p65-NF-kappaB translocation into the nucleus in RAW 264.7 cells. [1]
In vivo	Ceftiofur treatment is associated with a significant decrease in rectal temperature and diarrhea in neonatal calves. Ceftiofur results in a significant decrease in fecal shedding of Salmonella organisms in neonatal calves. [2] Ceftiofur hydrochloride (intrauterine (i.u.)) reduces the prevalence of positive uterineculture in cows with clinical endometritis (29.0 vs. 51.4%) and reduces the overall prevalence of Arcanobacterium pyogenes (1.0 vs. 7.6%) at 51 d in milk (DIM) . Ceftiofur hydrochloride reduces the prevalence of uterine infection in cows with clinical endometritis, and the prevalence of A. pyogenes, but does not affect the prevalence of subclinical endometritis or fertility of dairy cows already receiving PGF(2alpha). [3] Ceftiofur hydrochloride (i.m. injection) results in C(max) of 11.8 mg/mL at 1-4 hours after injection, the mean area under the curve (AUC) of 216 m g x h/mL in pigs. [4] Ceftiofur hydrochloride (2.2 mg of CE/kg, SC or IM, once daily for 5 days) is efficacious for treatment of acute postpartum metritis (APM) in dairy cows. [5]

Synonyms	Ceftiofur HCl, U-67279A, Excenel hydrochloride
Molecular Weight	560.02
Formula	C19H17N5O7S3·HCl
CAS No.	103980-44-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 21 mg/mL (37.5 mM)

DMSO: 93 mg/mL (166.1 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Ci X, et al. Biochem Biophys Res Commun,2008, 372(1), 73-77. 2. Fecteau ME, et al. Am J Vet Res,2003, 64(7), 918-925. 3. Galvão KN, et al. J Dairy Sci. 2009 Apr;92(4):1532-42. 4. Brown SA, et al. J Vet Pharmacol Ther,1999, 22(1), 35-40. 5. Chenault JR, et al. J Am Vet Med Assoc, 2004, 224(10), 1634-1639. 6. Fernández-Varón E, et al. Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of ceftiofur after a single intravenous, subcutaneous and subcutaneous-LA administration in lactating goats. BMC Vet Res. 2016 Oct 13;12(1):232.

Related compound libraries

This product is contained In the following compound libraries：

Immunology/Inflammation Compound Library Bioactive Compounds Library Max Antibiotics Library Drug-induced Liver Injury (DILI) Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library NO PAINS Compound Library Anti-Infection Compound Library Anti-COVID-19 Compound Library Beta-Lactam Compound Library

Related Products

Related compounds with same targets

N-Acetyl-Calicheamicin Nevadensin Azlocillin sodium salt Radezolid Ginkgolic Acid (C13:0) Gatifloxacin Florfenicol Clofoctol

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ceftiofur hydrochloride 103980-44-5 Microbiology/Virology Antibacterial Antibiotic inhibit Inhibitor Ceftiofur Bacterial Ceftiofur Hydrochloride Ceftiofur HCl U-67279A Excenel Hydrochloride Excenel hydrochloride inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.