Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Centanafadine hydrochloride (EB-1020 hydrochloride) is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 128.00 | |
10 mg | In stock | $ 213.00 | |
25 mg | In stock | $ 428.00 | |
50 mg | In stock | $ 688.00 | |
100 mg | In stock | $ 1,080.00 | |
200 mg | In stock | $ 1,450.00 | |
500 mg | In stock | $ 2,160.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 143.00 |
Description | Centanafadine hydrochloride (EB-1020 hydrochloride) is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter). |
Targets&IC50 | dopamine:38 nM (human), Norepinephrine (NE):6 nM (human), serotonin:83 nM(human) |
In vitro | Centanafadine (EB-1020) preferentially inhibits monoamine reuptake in cloned cell lines transfected with human transporters (IC50s: 6 and 38 nM), for NE and DA transporters, Centanafadine has lesser effects on 5-HT transporter as it inhibits the reuptake of 5-HT (IC50: 83 nM). |
In vivo | In microdialysis studies, Centanafadine markedly increases NE, and DA concentrations levels in rat prefrontal cortex in vivo with peak increases of 375 and 300%, respectively with the greatest effects on NE, and also increases DA extracellular concentrations in the striatum to 400% of baseline concentrations. Centanafadine dose-dependently decreases immobility in the mouse tail suspension test of depression to 13% of control levels, and do not stimulate locomotor activity in adult rats in the optimal dose range. Centanafadine dose-dependently inhibits locomotor hyperactivity in juvenile rats lesioned with the neurotoxin 6-hydroxydopamine (100 μg intracisternal) as neonates. |
Synonyms | EB-1020 hydrochloride |
Molecular Weight | 245.75 |
Formula | C15H16ClN |
CAS No. | 923981-14-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (508.65 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Centanafadine hydrochloride 923981-14-0 GPCR/G Protein Neuroscience Dopamine Receptor Serotonin Transporter Adrenergic Receptor Norepinephrine EB-1020 hydrochloride Centanafadine SLC6A3 5-HTT EB-1020 Hydrochloride EB 1020 Dopamine Transporter SLC6A4 Beta Receptor Centanafadine Hydrochloride DAT EB-1020 inhibit SERT EB1020 EB 1020 Hydrochloride EB1020 Hydrochloride Inhibitor inhibitor