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Cephaeline dihydrochloride

Catalog No. TQ0109 CAS 5853-29-2

Synonyms: (-)-Cephaeline dihydrochloride, NSC 32944

(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).

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Cephaeline dihydrochloride Chemical Structure

Cephaeline dihydrochloride, CAS 5853-29-2

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2 mg	5 days	$ 71.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).
Targets&IC50	CYP2D6:121 μM
In vitro	IC50 of Cephaeline against CYP2C9, CYP2D6, and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (Ki) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield Kis of 54 and 355 μM for CYP2D6 and CYP3A4, respectively.

Synonyms	(-)-Cephaeline dihydrochloride, NSC 32944
Molecular Weight	539.54
Formula	C28H40Cl2N2O4
CAS No.	5853-29-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Asano T, et al. Metabolism of ipecac alkaloids Cephaeline and Emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biol Pharm Bull. 2001 Jun;24(6):678-82.

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Keywords

Cephaeline dihydrochloride 5853-29-2 Metabolism P450 NSC32944 (-)-Cephaeline dihydrochloride Cephaeline Dihydrochloride NSC 32944 NSC-32944 Cephaeline inhibitor inhibit

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