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Ceramides Mixture

Catalog No. T10760 CAS 100403-19-8

Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activity.

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Ceramides Mixture, CAS 100403-19-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
2 mg	In stock	$ 45.00
5 mg	In stock	$ 74.00
10 mg	In stock	$ 108.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 272.00
100 mg	In stock	$ 397.00
500 mg	In stock	$ 936.00

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Purity: mixture

Biological Description

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Storage & Solubility Information

Description

In vitro

Endogenous Ceramides inhibits mRNA synthesis of telomerase reverse transcriptase and telomerase activity via inactivation of the c-Myc transcription factor in the A549 human lung adenocarcinoma cell line. The sustained generation of long-chain endogenous ceramide requires the biochemical recycling of the sphingosine backbone of C6-ceramide, which involves deacylation and reacylation of ceramide for the generation of endogenous long-chain ceramide, most likely by CoA-dependent ceramide synthase, which is inhibited by fumonisin B1. In A549 cells the generation of long-chain endogenous ceramide mediates the effects of exogenous C6-ceramide on growth inhibition, cell cycle arrest, and the modulation of telomerase activity [1].

Molecular Weight	581.967
Formula	C36H71NO4
CAS No.	100403-19-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Methanol: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 1mg/ml(1.72mM), Sonification and heating for 30 minutes are recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: < 1 mg/mL (insoluble or slightly soluble)

Chloroform: 7.69mg/ml (13.2mM)

References and Literature

1. Ogretmen B, et al. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. J Biol Chem. 2002 Apr 12;277(15):12960-9. 2. Macheleidt O, et al. Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. J Invest Dermatol. 2002 Jul;119(1):166-73.

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Keywords

Ceramides Mixture 100403-19-8 DNA Damage/DNA Repair Telomerase inhibit permeability transcription CoA Golgi Inhibitor mRNA c-Myc lipid cell-cycle barrier Endogenous inhibitor

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