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Cetrimonium bromide

Catalog No. T0497 CAS 57-09-0

Synonyms: Lauroseptol, Cetyltrimethylammonium Bromide, CTAB

Cetrimonium bromide (Lauroseptol) is is a mixture of different quaternary ammonium salts, which is a known component of the broad-spectrum antiseptic cetrimide.

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Cetrimonium bromide, CAS 57-09-0

Pack Size	Availability	Price/USD
50 mg	In stock	$ 30.00
100 mg	In stock	$ 39.00
200 mg	In stock	$ 55.00
500 mg	In stock	$ 91.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Cetrimonium bromide (Lauroseptol) is is a mixture of different quaternary ammonium salts, which is a known component of the broad-spectrum antiseptic cetrimide.
In vitro	In a FaDu xenograft tumor model established in SCID mice, intraperitoneal administration of 5 mg/kg Cetrimonium Bromide daily for five consecutive days moderately inhibited tumor growth as compared to the vehicle treatment arm. Additionally, 5 μM of Cetrimonium Bromide effectively prevented tumor formation in FaDu cells within SCID mice.
In vivo	Cetrimonium Bromide exhibits a dose-dependent and radiation potentiating interaction that inhibits the clonogenic survival of FaDu cells. It induces nuclear pyknosis and bubbling in FaDu cells, consistent with the morphology of apoptotic nuclei, which is not observed in CTAB-treated GM05757 cells. Additionally, it reproducibly suppresses ATPase activity in FaDu cells, achieving approximately 90% inhibition at 50 μM. Cetrimonium Bromide reduces the cell viability in a variety of cell lines including FaDu, C666-1, UTSCC-8A, UTSCC-42A, MRC5, and GM05757 fibroblasts, with respective EC50 values of 2 μM, 3.8 μM, 3.5 μM, 4.2 μM, 11 μM, and 18 μM. It also diminishes the cell viability of A549 lung and MCF7 breast cancer cells with EC50 values of 17 μM and 12 μM, respectively.

Synonyms	Lauroseptol, Cetyltrimethylammonium Bromide, CTAB
Molecular Weight	364.46
Formula	C19H42BrN
CAS No.	57-09-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (27.4 mM), Sonication is recommended.

Ethanol: 93 mg/mL (255.2 mM)

H2O: 100 mg/mL (274.4 mM)

References and Literature

1. Ito E, et al. Mol Pharmacol, 2009, 76(5), 969-983.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Infection Compound Library Bioactive Compounds Library Max Bioactive Compound Library NO PAINS Compound Library Antibiotics Library FDA-Approved & Pharmacopeia Drug Library Approved Drug Library Immunology/Inflammation Compound Library

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Keywords

Cetrimonium bromide 57-09-0 Microbiology/Virology Antibiotic Lauroseptol Inhibitor Cetyltrimethylammonium Cetyltrimethylammonium Bromide Hexadecyltrimethylammonium Cetrimonium inhibit CTAB Cetrimonium Bromide inhibitor

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