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Chebulic acid

Catalog No. TN1042   CAS 23725-05-5

Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits the formation of AGEs.It has effects against the progression of AGE-induced endothelial cell dysfunction,may constitute a promising intervention agent against diabetic vascular complications

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Chebulic acid Chemical Structure
Chebulic acid, CAS 23725-05-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 122.00
5 mg In stock $ 289.00
10 mg In stock $ 455.00
25 mg In stock $ 736.00
50 mg In stock $ 987.00
1 mL * 10 mM (in DMSO) In stock $ 318.00
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Purity: 99.98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits the formation of AGEs.It has effects against the progression of AGE-induced endothelial cell dysfunction,may constitute a promising intervention agent against diabetic vascular complications
In vitro chebulic acid prevents the glycer-AGEs-induced ROS formation of LX-2 cells and collagen accumulation by ERK-phosphorylation-mediated Nrf2 nuclear translocation, which causes upregulation of antioxidant protein production[2].
Source
Molecular Weight 356.24
Formula C14H12O11
CAS No. 23725-05-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 260 mg/mL (729.85 mM), sonification is recommended.

TargetMolReferences and Literature

1. Effects of chebulic acid on advanced glycation endproducts-induced collagen cross-links.Biol Pharm Bull. 2014;37(7):1162-7. Epub 2014 Apr 24. 2. Koo Y C , Pyo M C , Nam M H , et al. Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathway.[J]. Toxicology in Vitro, 2016, 34:8-15.

Related compound libraries

This product is contained In the following compound libraries:
Polyphenolic Natural Product Library Bioactive Compound Library Bioactive Compounds Library Max Antioxidant Compound Library Natural Product Library Natural Product Library for HTS Oxidation-Reduction Compound Library Selected Plant-Sourced Compound Library Food as Medicine Compound Library

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