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Chelidonine

Catalog No. T5S0055   CAS 476-32-4
Synonyms: Helidonine, Khelidonin, Stylophorin

1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Chelidonine Chemical Structure
Chelidonine, CAS 476-32-4
Pack Size Availability Price/USD Quantity
5 mg In stock $ 96.00
1 mL * 10 mM (in DMSO) In stock $ 74.00
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Purity: 99.44%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2.
Source
Synonyms Helidonine, Khelidonin, Stylophorin
Molecular Weight 353.37
Formula C20H19NO5
CAS No. 476-32-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 5 mg/mL(14.1 mM)

TargetMolReferences and Literature

1. Kim O , Hwangbo C , Kim J , et al. Chelidonine suppresses migration and invasion of MDA-MB-231 cells by inhibiting formation of the integrin-linked kinase/PINCH/α-parvin complex[J]. Molecular Medicine Reports, 2015.

TargetMolCitations

1. Liang X, Cao Y, Duan Z, et al.Discovery of New Small Molecule Inhibitors of the BPTF Bromodomain.Bioorganic Chemistry.2023: 106453.

Related compound libraries

This product is contained In the following compound libraries：
Anti-Cancer Active Compound Library Natural Product Library Alkaloid Natural Product Library Stem Cell Differentiation Compound Library Anti-virus Traditional Chinese Medicine Monomer Library RO5 Drug-like Natural Product Library Anti-Viral Compound Library Natural Product Library for HTS Anti-Tumor Natural Product Library Human Metabolite Library

Related Products

Related compounds with same targets
PG-11047 2HCl alpha-Mangostin Citicoline CPT2 LCS3 COG-1410 acetate Nutlin-3a UNC1215

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Keywords

Chelidonine 476-32-4 Apoptosis Microbiology/Virology Others Influenza Virus anticancer antiviral inhibit Helidonine melanoma cell Dugesia japonica Khelidonin Stylophorin Inhibitor isoquinoline alkaloid A-375 inhibitor

 

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