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Chitosan oligosaccharide

Catalog No. T10789   CAS 148411-57-8
Synonyms: COS

Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. It has the ability to activate AMPK and simultaneously inhibit inflammatory signaling pathways, including NF-κB and MAPK.

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Chitosan oligosaccharide Chemical Structure
Chitosan oligosaccharide, CAS 148411-57-8
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. It has the ability to activate AMPK and simultaneously inhibit inflammatory signaling pathways, including NF-κB and MAPK.
In vitro Activation of AMPK and inhibition of inflammatory signaling pathways including NF-κB and MAPK pathways are recognized as major mechanisms responsible for several effects of Chitosan oligosaccharide (COS) including anti-inflammation, anti-cancer, and anti-diabetes. COS can interrupt cancer progression at multiple stages by modulating several signaling proteins/pathways including AMPK, NF-κB, mTOR, CD147, caspase-3, MMP-2, MMP-9, and VEGF. In vitro experiments have demonstrated that Chitosan oligosaccharide induced the death of several cancer cell types including ascites, bladder cancer, prostate cancer, lung cancer, liver cancer, leukemia, cervical cancer, and colorectal cancer. The values of IC50 of Chitosan oligosaccharide in inducing cytotoxicity are 25 μg/mL-50 μg/mL depending on types of cancer cells [1].
In vivo Administering Chitosan oligosaccharide orally at a dose of 16 mg/kg/day effectively reduces the production of proinflammatory cytokines (IL-4, IL-13, and TNF-α) associated with allergic reactions in both lung tissue and the bronchoalveolar lavage fluid of mice. Additionally, this compound demonstrates an anti-inflammatory effect on lymphocyte activation in a rat model of autoimmune anterior uveitis, which is induced by immunization with bovine melanin-associated antigen [1]. Moreover, Chitosan oligosaccharide has shown to mitigate the effects of UV-induced damage in mouse skin, evident by preventing skin erythema, dryness, thickening, sagging, coarse wrinkles, and even the development of leathery appearance and slight flesh-colored lesions caused by 10 weeks of UV exposure. This contrasts significantly with the smoother, less wrinkled skin observed in the control group of hairless mice, as quantitatively supported by a significantly higher visual score in the model group (p<0.05) [2].
Synonyms COS
Molecular Weight 340.327
Formula C12H24N2O9
CAS No. 148411-57-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL, sonification is recommended.

DMSO: 50 mg/mL (146.92 mM), Sonification is recommended

TargetMolReferences and Literature

1. Muanprasat C, et al. Chitosan oligosaccharide: Biological activities and potential therapeutic applications. Pharmacol Ther. 2017 Feb;170:80-97 2. Kong SZ, et al. Anti-photoaging effects of chitosan oligosaccharide in ultraviolet-irradiated hairless mouse skin. Exp Gerontol. 2018 Mar;103:27-34.

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Keywords

Chitosan oligosaccharide 148411-57-8 Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK inhibit COS Inhibitor AMP-activated protein kinase inhibitor

 

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