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Chlorcyclizine hydrochloride

Catalog No. T10794 CAS 14362-31-3

Chlorcyclizine hydrochloride is an antagonist of histamine H1.

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Chlorcyclizine hydrochloride, CAS 14362-31-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Chlorcyclizine hydrochloride is an antagonist of histamine H1.

In vivo

Pregnant rats administered 30, 60, and 90mg/kg Chlorcyclizine during the sensitive period for palate development survived until scheduled sacrifice on Gestation Days (GDs) 17 or 21. The rats administered 60 or 90mg/kg Chlorcyclizine have transient adverse clinical signs and a concomitant body weight loss of 7% and 11%, respectively, over the dosing interval. Rats administered 30mg/kg Chlorcyclizine do not exhibit any adverse clinical signs, but do not gain weight over the dosing interval as would be expected during pregnancy.

Molecular Weight	337.29
Formula	C18H22Cl2N2
CAS No.	14362-31-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 77.5 mg/mL (229.77 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Enright BP, et al. Effects of the histamine H1 antagonist Chlorcyclizine on rat fetal palate development. Birth Defects Res B Dev Reprod Toxicol. 2010 Dec;89(6):474-84.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Chlorcyclizine hydrochloride 14362-31-3 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor Inhibitor inhibitor inhibit

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