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Chlorpheniramine maleate

Catalog No. T1553   CAS 113-92-8
Synonyms: NCI-C55265, Chlorphenamine maleate

Chlorpheniramine maleate (NCI-C55265) is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma.

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Chlorpheniramine maleate Chemical Structure
Chlorpheniramine maleate, CAS 113-92-8
Pack Size Availability Price/USD Quantity
200 mg In stock $ 29.00
1 mL * 10 mM (in DMSO) In stock $ 30.00
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Purity: 99.67%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Chlorpheniramine maleate (NCI-C55265) is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma.
Targets&IC50 Histamine H1 receptor:12 nM
Kinase Assay H1-Antihistaminic Activity: The segments (1 cm) of isolated ileum from guinea pigs are suspended in an organ bath containing Tyrode solution (ventilation, 32 °C). The contractile responses to histamine (0.54 μM) are measured with an isotonic transducer. A set concentration of Chlorpheniramine is added in the organ bath 5 minutes before the addition of histamine. IC50 value of Chlorpheniramine is calculated by the probit methond.
Cell Research Cells are exposed to various concentrations of Chlorpheniramine for 48 hours. Cells are washed, detached, and counted with a Coulter counter for the determination of cell growth.(Only for Reference)
Synonyms NCI-C55265, Chlorphenamine maleate
Molecular Weight 390.87
Formula C20H23ClN2O4
CAS No. 113-92-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (127.92 mM)

DMSO: 100 mg/mL (255.84 mM)

TargetMolReferences and Literature

1. Iemura R, et al. J Med Chem, 1986, 29(7), 1178-1183. 2. Sleevi MC, et al. J Med Chem, 1991, 34(4), 1314-1328. 3. Medina MA, et al. Breast Cancer Res Treat, 1995, 35(2), 187-194. 4. Kelly JX, et al. Antimicrob Agents Chemother, 2007, 51(11), 4133-4140. 5. Kim JH, et al. J Pharmacol Exp Ther, 2009, 330(2), 403-412.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Neuronal Signaling Compound Library Histamine & Melatonin Receptor-Targeted Compound Library NO PAINS Compound Library Anti-Cardiovascular Disease Compound Library Drug Repurposing Compound Library Immunology/Inflammation Compound Library Anti-Obesity Compound Library

Related Products

Related compounds with same targets
Emedastine Betahistine dihydrochloride Nortriptyline hydrochloride Dexchlorpheniramine Maleate Cyproheptadine hydrochloride sesquihydrate Clemizole Hydroxyzine Pamoate 3,5-Dicaffeoyl-epi-quinic acid

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Keywords

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