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Chondroitin sulfate

Catalog No. T2980 CAS 9007-28-7

Synonyms: Chonsurid, Chondroitin polysulfate

Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry condition

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Chondroitin sulfate, CAS 9007-28-7

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 32.00
1 g	In stock	$ 68.00

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Purity: 99.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry condition
In vitro	Chondroitin sulfate, a sulfated glycosaminoglycan comprising linear polysaccharides with repeating disaccharide units of uronic acid and N-acetylhexosamine, plays a critical role in the extracellular matrix of various connective tissues, including bone, cartilage, skin, ligaments, and tendons. It has been observed that various pathogens such as parasites, bacteria, and viruses exploit chondroitin sulfate on the cell surface for host cell attachment and infection. Beyond its natural occurrence, chondroitin sulfate exhibits multiple beneficial properties, including anti-inflammatory effects, promotion of type II collagen and proteoglycan production, reduction in bone resorption, and support for a positive anabolic/catabolic balance in chondrocytes. In vitro studies have employed a broad spectrum of chondroitin sulfate concentrations, typically not exceeding 200 mg/mL, demonstrating its capability to diminish chondrocyte vulnerability to apoptosis triggered by single nucleotide polymorphism at 200 mg/mL concentration. Moreover, it significantly lowers the levels of inflammation mediators, the apoptotic process, and inflammatory cytokine, iNOS, and MMPs production.
In vivo	The high content of chondroitin sulfate in aggrecan significantly contributes to cartilage's ability to withstand tensile stresses under various loading conditions, endowing the tissue with enhanced resistance and elasticity. Research indicates that chondroitin sulfate plays a role in mitigating the progression of structural changes in joint tissues, thereby supporting its use in treating osteoarthritis patients. Administered orally in dosages between 800 to 1200 mg/day, chondroitin sulfate is quickly absorbed by the gastrointestinal tract. Once absorbed, it enters the bloodstream as 10% unchanged chondroitin sulfate and 90% as depolymerized low-molecular-weight derivatives.
Cell Research	Chondrocytes are cultured into six-well culture plates. 12 hours after plating, the culture medium is replaced with 2.0 mL of fresh medium containing LPS at a concentration of 50 mg/mL. 4 hours later, HA, Chondroitin sulfate, HS, keratan sulphate and DS are added separately to each of the wells at concentrations of 0.5 and 1.0 mg/mL. The number of viable chondrocytes is then quantified by trypan blue dye exclusion test from several randomly chosen areas of each well[4].

Synonyms	Chonsurid, Chondroitin polysulfate
Molecular Weight	3-5w kDa
Formula	(C14H21NO14S)n
CAS No.	9007-28-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

References and Literature

1. Mikami T, et al. Biosynthesis and function of chondroitin sulfate. Biochim Biophys Acta. 2013 Oct;1830(10):4719-33. 2. Martel-Pelletier J, et al.Discrepancies in composition and biological effects of different formulations of chondroitin sulfate. Molecules. 2015 Mar 6;20(3):4277-89. 3. Monfort J, et al. Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues. Ann Rheum Dis. 2008 Jun;67(6):735-40. 4. Campo GM, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92. 5. Henrotin Y, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinicalrecommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48.

Citations

1. Zheng K, Ma Y, Chiu C, et al. Co-culture pellet of human Wharton’s jelly mesenchymal stem cells and rat costal chondrocytes as a candidate for articular cartilage regeneration: in vitro and in vivo study. Stem Cell Research & Therapy. 2022, 13(1): 1-15. 2. Chiu C, Zheng K, Xue M, et al.Comparative Analysis of Hyaline Cartilage Characteristics and Chondrocyte Potential for Articular Cartilage Repair.Annals of Biomedical Engineering.2024: 1-14.

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Keywords

Chondroitin sulfate 9007-28-7 Immunology/Inflammation Metabolism Others Proteases/Proteasome MMP NO Synthase Endogenous Metabolite NOS Matrix metalloproteinases Nitric oxide synthases Chondroitin Inhibitor Chonsurid inhibit Chondroitin Sulfate Chondroitin polysulfate inhibitor

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