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Cilazapril Monohydrate

Catalog No. T6444 CAS 92077-78-6

Synonyms: Ro 31-2848 monohydrate, Justor

Cilazapril Monohydrate (Justor) is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.

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Cilazapril Monohydrate Chemical Structure

Cilazapril Monohydrate, CAS 92077-78-6

Pack Size	Availability	Price/USD
5 mg	4-6weeks	$ 58.00
10 mg	4-6weeks	$ 94.00
25 mg	4-6weeks	$ 198.00
50 mg	4-6weeks	$ 347.00
100 mg	4-6weeks	$ 648.00
1 mL * 10 mM (in DMSO)	4-6weeks	$ 81.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cilazapril Monohydrate (Justor) is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.
In vitro	BML-190 has 50-fold selectivity for CB2 receptors over CB1 receptors. In HEK-293 cells stably expressing the human CB2 receptor, BML-190 potentiates the forskolin-stimulated accumulation of cAMP. BML-190 reduces the basal levels of inositol phosphate production in cells expressing the CB2 receptor. 10 μM of BML-190 decreases inositol phosphates accumulation by 38%. [1] BML-190 is an aminoalkylindole. BML-190 is found to yield at least 15 metabolic products. [2] BML-190 diminishes LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibits LPS-induced PGE2 production and COX-2 induction. [3]
In vivo	Cilazapril (1 mg/kg, daily) tends to decrease and the higher dose (10 mg/kg, daily) significantly decreases systolic blood pressure (SBP) in subtotal nephrectomized rats. Cilazapril attenuates the further development of protein uria in a dose-dependent manner in subtotal nephrectomized rats. Cilazapril attenuates the increase in plasma fibrinogen concentration and serum albumin concentration in a dose-dependent manner. Cilazapril reduces serum MCP-1 concentration in the nephrectomized rats. Cilazapril decreases hepatic fibrinogen synthesis through the alleviation of the local inflammatory process and the improvement of hypoalbuminemia. [1] Cilazapril normalizes systolic arterial pressure to 121 mm Hg (SD) in the treated SHR-SP rats. Cilazapril decreases systolic arterial pressure to a nearly normal level and prevents hypertensive retinal vascular changes, probably by improving endothelial function. [2] Cilazapril results in a marked decrease in the Kd of the renal arginine vasopressin (AVP) receptor and an increase in the plasma AVP level in the spontaneously hypertensive rat. [3] Cilazapril exerts a rapid, complete, and persistent antihypertensive effect in the spontaneously hypertensive rats (SHR) in vivo but has no effect on SAP in the normotensive Sprague-Dawley rat. Cilazapril treatment depresses heart performance (28-35%) in SHR but has no effect in the Sprague-Dawley rats. [4] Cilazapril decreases blood pressure to control values and reduces HW:BW in hyperthyroid rats. [5]

Synonyms	Ro 31-2848 monohydrate, Justor
Molecular Weight	435.51
Formula	C22H31N3O5·H2O
CAS No.	92077-78-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 81 mg/mL (186 mM)

H2O: <1 mg/mL

DMSO: 81 mg/mL (186 mM)

References and Literature

1. Sugimoto K, et al. J Pharmacol Sci, 2004, 94(1), 67-72. 2. Bhutto IA, et al. Life Sci, 1999, 64(3), PL27-39. 3. Nishida N, et al. Res Commun Chem Pathol Pharmacol, 1994, 84(2), 143-152. 4. Christe ME, et al. Am J Physiol, 1994, 267(5 Pt 2), H2050-2057. 5. Asahi T, et al. Thyroid, 2001, 11(11), 1009-1015.

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Keywords

Cilazapril Monohydrate 92077-78-6 Endocrinology/Hormones RAAS Angiotensin-converting Enzyme (ACE) Ro 31-2848 monohydrate Justor Inhibitor Ro 31-2848 Monohydrate Ro 31-2848 inhibit Cilazapril inhibitor

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