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Cilnidipine

Catalog No. T0388 CAS 132203-70-4

Synonyms: FRC-8653

Cilnidipine (FRC-8653)(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.

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Cilnidipine, CAS 132203-70-4

Pack Size	Availability	Price/USD
10 mg	In stock	$ 41.00
50 mg	In stock	$ 81.00
100 mg	In stock	$ 134.00
200 mg	In stock	$ 167.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cilnidipine (FRC-8653)(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.
In vitro	Cilnidipine inhibits the rise in blood urea nitrogen and the decline in creatinine clearance, as well as the progression of glomerulosclerosis. It prevents the increased content of renal angiotensin II, the expression of NADPH oxidase, and the augmented membrane translocation of dihydroethidium in SHR/ND rats. Administering 30 mg/kg of Cilnidipine daily to Dahl salt-sensitive rats effectively treated the elevation of systolic blood pressure. Compared to control-treated Dahl S rats, Cilnidipine reduced plasma norepinephrine levels and plasma renin activity. In spinal cord destruction rats, it suppressed the pressor responses induced by sympathetic nerve stimulation and angiotensin II. In anesthetized rats, Cilnidipine, or omega-conotoxin MVIIA, lowered mean arterial blood pressure with a slight increase in heart rate. At antihypertensive doses in rats, Cilnidipine affected sympathetic nerve N-type calcium channels (Ca(2+)), besides vascular L-type channels. Following NMDA receptor activation, Cilnidipine reduced Ca(2+) influx through N-type channels, and in rats in vivo, it protected neurons from ischemic reperfusion injury in the retina. Compared to amlodipine-treated spontaneously hypertensive rats/ND mcr-cp (SHR/ND), Cilnidipine significantly prevented the increase in fibrillary protein staining and restored the expression of podocin and nephrin in the glomeruli.
In vivo	Cilnidipine at 10 mM can inhibit the increase in the ratio induced by 40 mM potassium chloride, and is also effective in inhibition when treated with omega-conotoxin GVIA.

Synonyms	FRC-8653
Molecular Weight	492.52
Formula	C27H28N2O7
CAS No.	132203-70-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 49.3 mg/mL (100 mM)

Ethanol: 4.9 mg/mL (10 mM)

References and Literature

1. Takahara A, et al. Hypertens Res,2003, 26(9), 743-747. 2. Sakamoto K, et al. Exp Eye Res,2009, 88(5), 974-982. 3. Fan YY, et al. J Hypertens,2010, 28(5), 1034-1043. 4. Konda T, et al. Biol Pharm Bull,2006, 29(5), 933-937. 5. Takahara A, et al. Eur J Pharmacol,2002, 434(1-2), 43-47.

Citations

1. Wang B, Pei J, Zhang H, et al.Dihydropyridine-derived calcium channel blocker as a promising anti-hantavirus entry inhibitor.Interventions for emerging infectious diseases.2023, 16648714.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-COVID-19 Compound Library Neuronal Signaling Compound Library Anti-Cardiovascular Disease Compound Library Ion Channel Inhibitor Library

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Keywords

Cilnidipine 132203-70-4 Membrane transporter/Ion channel Metabolism Calcium Channel FRC8653 FRC-8653 Ca2+ channels inhibit Inhibitor Ca channels FRC 8653 channel Antihypertensive dihydropyridine Ca long-acting inhibitor

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