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Cilostazol

Catalog No. T0462 CAS 73963-72-1

Synonyms: OPC 21, OPC 13013

Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.

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Cilostazol, CAS 73963-72-1

Pack Size	Availability	Price/USD
25 mg	In stock	$ 39.00
50 mg	In stock	$ 53.00
100 mg	In stock	$ 77.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 99.87%

Purity: 99.86%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.
Targets&IC50	PDE3:0.2 μM
In vivo	Cilostazol induces relaxation of vascular smooth muscle and causes vasodilation. It inhibits the expression of monocyte chemotactic protein-1 (MCP-1) induced by cytokines. Additionally, Cilostazol reduces plasma triglycerides and increases high-density lipoprotein (HDL) levels. The vasodilatory and antithrombotic effects of Cilostazol are primarily due to the inhibition of phosphodiesterase 3 (PDE3) and the subsequent elevation of intracellular cyclic adenosine monophosphate (cAMP) levels. It also inhibits platelet aggregation and adenosine uptake.

Synonyms	OPC 21, OPC 13013
Molecular Weight	369.46
Formula	C20H27N5O2
CAS No.	73963-72-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 18.5 mg/mL (50 mM)

Ethanol: 3.7 mg/mL (10 mM)

References and Literature

1. Cone J, et al. J Cardiovasc Pharmacol, 1999, 34(4), 497-504. 2. Liu Y, et al. Cardiovasc Drug Rev, 2001, 19(4), 369-386. 3. Sun B, et al. J Cardiovasc Pharmacol, 2002, 40(4), 577-585. 4. Schrör K. et al. Diabetes Obes Metab, 2002, 4 Suppl 2, S14- S19.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Cuproptosis Compound Library FDA-Approved & Pharmacopeia Drug Library Drug-induced Liver Injury (DILI) Compound Library Bioactive Lipid Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cilostazol 73963-72-1 Autophagy Metabolism PDE OPC-21 late fibrogenesis OPC-13013 cardiovascular inhibit OPC21 OPC 21 injury hepatic OPC13013 Phosphodiesterase (PDE) OPC 13013 Inhibitor inhibitor

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