Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 140.00 | |
25 mg | 6-8 weeks | $ 766.00 | |
50 mg | 6-8 weeks | $ 996.00 | |
100 mg | 6-8 weeks | $ 1,540.00 |
Description | Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome. |
In vitro | Cimetropium reduces the release of labeled acetylcholine (ACh) elicited by electrical field stimulation, particularly when muscarinic autoinhibition is blocked, as observed in superfusion experiments using preparations preloaded with labeled choline [2]. Furthermore, it exhibits a powerful antimuscarinic action by inhibiting the contraction of longitudinal muscle preparations. As a competitive antagonist, Cimetropium Bromide effectively counteracts muscarinic-mediated contractions in isolated colonic preparations from various species, demonstrating affinity values (pA2) between 7.41 and 7.82 [1]. |
In vivo | Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration (ID50: 27.9 μg/kg); both tonic and phasic components of contractile response are affected. Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli when administered intravenously to conscious dogs provided with a colonic Thiry fistula. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension [1]. |
Synonyms | DA-3177 |
Molecular Weight | 438.36 |
Formula | C21H28BrNO4 |
CAS No. | 51598-60-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (114.06 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Cimetropium Bromide 51598-60-8 Neuroscience AChR DA 3177 DA3177 DA-3177 inhibitor inhibit