Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cinanserin hydrochloride (SQ 10643) is a high affinity antagonist of the 5-HT2 receptor (Ki: 41 nM) and a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 68.00 | |
10 mg | In stock | $ 109.00 | |
25 mg | In stock | $ 218.00 | |
50 mg | In stock | $ 397.00 | |
100 mg | In stock | $ 597.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 119.00 |
Description | Cinanserin hydrochloride (SQ 10643) is a high affinity antagonist of the 5-HT2 receptor (Ki: 41 nM) and a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus. |
Targets&IC50 | 5-HT2 receptor:41 nM (ki), 3CLpro: |
In vitro | Cinanserin and Cinanserin hydrochloride inhibit the catalytic activity of SARS-CoV 3CLpro and HCoV-229E 3CLpro (IC50: 4.68 μM and 5.68 μM). Cinanserin/Cinanserin hydrochloride has a binding affinity to SARS-CoV 3CLpro, HCoV-229E 3CLpro, with the KD values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CLpro[1]. |
In vivo | Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels[2]. |
Synonyms | SQ 10643 |
Molecular Weight | 376.94 |
Formula | C20H25ClN2OS |
CAS No. | 54-84-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (331.62 mM), Sonication is recommended.
H2O: 100 mg/mL (265.29 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Cinanserin hydrochloride 54-84-2 GPCR/G Protein Microbiology/Virology Neuroscience Influenza Virus 5-HT Receptor edema replication Serotonin Receptor leukocyte virus burn 3C-like Cinanserin Hydrochloride proteinase endothelial Cinanserin SQ-10643 Inhibitor 5-hydroxytryptamine Receptor systemic inhibit 5-HT2 SQ 10643 SQ10643 inhibitor