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Citalopram hydrobromide

Catalog No. T1483 CAS 59729-32-7

Synonyms: Lu 10-171, Nitalapram HBr, Bonitrile HBr, XU-62-320, Lu 10-171 HBr, Citalopram HBr

Citalopram hydrobromide (XU-62-320) , a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system (CNS). Citalopram hydrobromide is the orally bioavailable hydrobromide salt of the racemic bicyclic phthalene derivative citalopram with antidepressant activity. This agent has minimal effects on the CNS neuronal reuptake of norepinephrine (NE) and dopamine (DA).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Citalopram hydrobromide Chemical Structure

Citalopram hydrobromide, CAS 59729-32-7

Pack Size	Availability	Price/USD
10 mg	In stock	$ 40.00
25 mg	In stock	$ 65.00
50 mg	In stock	$ 82.00
100 mg	In stock	$ 112.00
200 mg	In stock	$ 157.00
500 mg	In stock	$ 259.00

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Purity: 99.35%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Citalopram hydrobromide (XU-62-320) , a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system (CNS). Citalopram hydrobromide is the orally bioavailable hydrobromide salt of the racemic bicyclic phthalene derivative citalopram with antidepressant activity. This agent has minimal effects on the CNS neuronal reuptake of norepinephrine (NE) and dopamine (DA).
Targets&IC50	5-HT receptor:1.8 nM
In vitro	Citalopram (Lu 10-171), a new bicyclic phthalane derivative, is an extremely potent inhibitor of neuronal serotonin (5-HT) uptake but has no effect on the uptake of noradrenaline(NA) and dopamine (DA) and no antagonistic activity towards 5-HT, histamine, gamma aminobutyric acid (GABA), acetylcholine, and morphine receptors. It is an extremely specific and potent inhibitor of neuronal 5-HT uptake. Uptake mechanisms for other transmitter amines are not influenced by the drug[1]. The SSRI citalopram has a greater effect on proliferation and a lesser effect on apoptotic activity. It affects cell cycle regulation by increasing proliferative potential and decreasing apoptotic activity in a site specific manner that may be indicative of hyperplasia. Citalopram alters FGF, MSX and TGFB expression in osteoblast cell culture[3].
In vivo	Citalopram is devoid of cardiotoxic effects even when animals are exposed to concentrations far above the therapeutic level. In man citalopram is metabolized to compounds which are also potent 5-HT-uptake inhibitors without effect on noradrenaline(NA) uptake and which are found in lower concentrations than citalopram itself. Citalopram (1-16 mg/kg) stimulates the hind limb flexor reflex in the spinal rat. Citalopram potentiates 5-HT transmission~ possibly by producing very strong uptake inhibition without simultaneously blocking the post-synaptic 5-HT receptors[1].
Cell Research	Cells are cultured in alpha minimum Eagles medium supplemented with 1% penicillin/streptomycin, 10% fetal bovine serum and Amphotericin B. For control data, cells are cultured for 3 or 7 days with standard alpha proliferation media. For SSRI treatments, media is supplemented with citalopram eluted to serially diluted doses between 10?4 mol through 10?10 mol to achieve a dose response curve.(Only for Reference)

Synonyms	Lu 10-171, Nitalapram HBr, Bonitrile HBr, XU-62-320, Lu 10-171 HBr, Citalopram HBr
Molecular Weight	405.304
Formula	C20H22BrFN2O
CAS No.	59729-32-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 6 mg/mL(14.8 mM)

H2O: 4 mg/mL(9.9 mM)

References and Literature

1. Hyttel J. Prog Neuropsychopharmacol Biol Psychiatry. 1982, 6(3):277-95. 2. Pollier F, et al. Neuropsychopharmacology. 2000, 22(1):64-76. 3. Durham E, et al. PLoS One. 2015, 10(10):e0139719.

Citations

1. Yang D, Liu H, Cai Y, et al. Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression. Cell Reports. 2022, 41(8): 111691.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cancer Approved Drug Library Membrane Protein-targeted Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library GPCR Compound Library Anti-Cancer Drug Library FDA-Approved Drug Library

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Keywords

Citalopram hydrobromide 59729-32-7 Autophagy GPCR/G Protein Neuroscience 5-HT Receptor Serotonin Transporter Citalopram SLC6A4 Lu 10-171 SERT serotonin Nitalapram HBr selective 5-HTT 5-HT,Antidepressant Bonitrile HBr (±)-Citalopram XU-62-320 Citalopram Hydrobromide reuptake Lu 10-171 HBr inhibitor inhibit SSRI Citalopram HBr

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