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Clindamycin hydrochloride

Catalog No. T6448 CAS 21462-39-5

Synonyms: Sobelin HCl, Cleocin, Clindamycin HCl, Clinimycin HCl

Clindamycin hydrochloride (Clinimycin HCl) inhibits protein synthesis by acting on the 50S ribosomal. It is the hydrochloride salt form of clindamycin, a semi-synthetic, chlorinated broad-spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin hydrochloride(Clinimycin HCl) is used as a solid in capsules.

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Clindamycin hydrochloride Chemical Structure

Clindamycin hydrochloride, CAS 21462-39-5

Pack Size	Availability	Price/USD
50 mg	In stock	$ 40.00
100 mg	In stock	$ 48.00
200 mg	In stock	$ 59.00
1 g	In stock	$ 91.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Clindamycin hydrochloride (Clinimycin HCl) inhibits protein synthesis by acting on the 50S ribosomal. It is the hydrochloride salt form of clindamycin, a semi-synthetic, chlorinated broad-spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin hydrochloride(Clinimycin HCl) is used as a solid in capsules.
In vitro	Clindamycin is a classical inhibitor of bacterial protein synthesis which binds to the 23S ribosomal RNA of the 50S ribosomal subunit. [1]
In vivo	Clindamycin hydrochloride is rapidly absorbed orally in dogs, exhibiting a mean absorption time (MAT) of 0.87 hours and a bioavailability of 72.55%. It shows a total clearance (CL) rate post intravenous (IV) and oral administration of 0.503 and 0.458 L/h/kg respectively, and reaches a steady-state volume of distribution (IV) of 2.48 L/kg, indicating extensive distribution throughout the body's fluids and tissues. Serum concentrations of clindamycin remain above 0.5 μg/mL for approximately 10 hours after both IV and oral administration. [1] Additionally, it significantly reduces oral malodor, dental plaque, dental calculus, and gingival bleeding in dogs over a period of 42 days. [2] At a dosage of 2.5 mg/lb following ultrasonic scaling, root planing, and polishing (USRP), clindamycin significantly impacts plaque and pocket depth related to periodontal disease, though not gingivitis. [3] Furthermore, it achieves a complete remission ratio of 71.4% (15/21) in dogs with canine superficial bacterial pyoderma within 14 to 28 days. [4]
Kinase Assay	In vitro potency assays: After RO4929097 is used, the Aβ peptides are measured by ECL assays using a variety of anti-Aβ antibodies and an Origen 1.5 Analyzer. The 4 g8 murine mAb binds an epitope in the Aβ peptide (within amino acids 18–21) that is immediately distal to the α-secretase cleavage site. The G2–10 murine mAb binds the C terminus that is exposed after γ-secretase-mediated cleavage to generate amino acid 40 of the Aβ40 peptide. The FCA3542 rabbit antibody binds the C terminus that is exposed after γ-secretase-mediated cleavage to generate amino acid 42 of the Aβ42 peptide. The 4 g8 mAb is biotinylated with biotin-LC-sulfo-N-hydroxysuccinimide-ester. The G2–10 and FCA3542 antibodies are ruthenylated with TAG-N-hydroxysuccinimide ester. Aβ(x-40) is detected with biotinylated 4 g8 and ruthenylated G2–10. Aβ(x-42) is detected with biotinylated 4 g8 and ruthenylated FCA3542.

Synonyms	Sobelin HCl, Cleocin, Clindamycin HCl, Clinimycin HCl
Molecular Weight	461.44
Formula	C18H33ClN2O5S·HCl
CAS No.	21462-39-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 46.1 mg/mL (100 mM)

References and Literature

1. Batzias GC, et al. Vet J,2005, 170(3), 339-345. 2. Warrick JM, et al. Vet Ther,2000, 1(1), 5-16. 3. Nielsen D, et al. Vet Ther, 2000, 1(3), 150-158. 4. Bloom PB, et al. J Am Anim Hosp Assoc,2001, 37(6), 537-542.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library FDA-Approved Drug Library Bioactive Compounds Library Max Orally Active Compound Library Anti-Infection Compound Library Clinical Compound Library Bioactive Compound Library NO PAINS Compound Library Approved Drug Library

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Keywords

Clindamycin hydrochloride 21462-39-5 Microbiology/Virology Antibacterial Antibiotic inhibit Inhibitor Clindamycin Sobelin HCl Bacterial Cleocin Clindamycin Hydrochloride Clindamycin HCl Clinimycin HCl inhibitor

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