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Clinofibrate

Catalog No. T6450 CAS 30299-08-2

Synonyms: S-8527, Lipoclin

Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood.

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Clinofibrate, CAS 30299-08-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 55.00
25 mg	In stock	$ 113.00
50 mg	In stock	$ 183.00
100 mg	In stock	$ 289.00
200 mg	In stock	$ 428.00
1 mL * 10 mM (in DMSO)	In stock	$ 40.00

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Purity: 99.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood.
Targets&IC50	HMG-CoA reductase:0.47 mM
In vitro	In the treatment of arteriosclerosis in rats, Clinofibrate significantly reduces high plasma cholesterol levels. When used in CAPD patients, it effectively decreases very low-density lipoprotein levels. Typically, Clinofibrate (600 mg/daily) reduces serum triglycerides by 36% and very low-density lipoprotein triglycerides by 48%. Additionally, it ameliorates abnormalities in low-density and high-density lipoprotein compositions, markedly increasing the content of high-density lipoprotein cholesterol.
In vivo	Clinofibrate, with an IC50 of 40 μM, acts on the activity of human liver 3α-hydroxysteroid dehydrogenase.

Synonyms	S-8527, Lipoclin
Molecular Weight	468.58
Formula	C28H36O6
CAS No.	30299-08-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 87 mg/mL (185.7 mM)

Ethanol: 87 mg/mL (185.7 mM)

References and Literature

1. Matsuura K, et al, J Pharmacol Exp Ther, 1998, 285(3), 1096-1103. 2. Shirai K, et al, Artery, 1983, 12(3), 145-155.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Inhibitor Library Bioactive Lipid Compound Library Anti-Metabolism Disease Compound Library Bioactive Compounds Library Max Anti-Cancer Metabolism Compound Library Anti-Cardiovascular Disease Compound Library Lipid Metabolism Compound Library

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Keywords

Clinofibrate 30299-08-2 Autophagy Metabolism HMG-CoA Reductase S 8527 S-8527 HMG-CoA Reductase (HMGCR) inhibit Inhibitor S8527 Lipoclin inhibitor

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