Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 34.00 | |
100 mg | In stock | $ 54.00 | |
200 mg | In stock | $ 81.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 37.00 |
Description | Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals. |
In vitro | Closantel (7.5 mg/kg) in combination with a broad-spectrum anthelmintic shows moderate efficacy against caprine Trichostrongylus spp, but is highly effective against Haemonchus contortus. In mice with Fasciola hepatica metacercarial cysts, treatment with closantel (10 mg/kg) leads to extensive peeling on the anterior and posterior extremities, as well as the dorsal and ventral surfaces, resulting in significant overall dermal damage 24 hours post-administration. Furthermore, in sheep infected with resistant H. contortus strains, isotope levels following treatment with radiolabeled closantel are significantly lower compared to susceptible worms. |
In vivo | Compared to normal conditions, Closantel (50 μg/mL) induces vascular tissue to contract with greater amplitude and higher frequency, reaching a peak muscle tension after approximately 15 minutes, with the amplitude exceeding 1.5 times that of the maximum normal contraction. Additionally, Closantel effectively blocks the infection of host cells by A. phagocytophilum or E. chaffeensis and can clear infections after a one-day treatment in a dose-dependent manner. It also inhibits drug-resistant Enterococcus faecium and Staphylococcus aureus, with minimum inhibitory concentrations (MICs) of 1 μg/mL, and Methicillin-resistant Staphylococcus aureus (MRSA) with a MIC of 2 μg/mL. Moreover, Closantel inhibits the autophosphorylation activity of three sensor kinases derived from E. chaffeensis. |
Synonyms | R-31520 |
Molecular Weight | 663.07 |
Formula | C22H14Cl2I2N2O2 |
CAS No. | 57808-65-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 93 mg/mL (140.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Closantel 57808-65-8 Microbiology/Virology Parasite Antibacterial R31520 halogenated R-31520 Inhibitor Onchocerca OvCHT1 fromprotozoans chitinase O. volvulus inhibit R 31520 salicylanilide chitotriosidase volvulus inhibitor