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Clovamide

Catalog No. T26288 CAS 53755-02-5

Synonyms: trans-Clovamide, N-trans-Caffeoy-L-dopa

Trans-Clovamide (trans-Clovamide) is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprotective effects (EC50s = 0.9-3.7 µM) in several in vitro models of neuronal death. Trans-Clovamide is an excellent ROS and oxygen radical scavenger and also has anti-inflammatory and neuroprotective effects. Clovamide is an anti-microbial with activity against the human pathogens influenza A subtype H5N1, Trypanosoma evansi, and Heliobacter pylori.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Clovamide, CAS 53755-02-5

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 139.00
50 mg	In stock	$ 247.00
100 mg	In stock	$ 422.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 96.70%

Purity: 96.47%

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Description

In vitro

Clovamide protects neurons from injury in three in vitro models of neuronal death: oxidative stress, excitotoxicity and OGD/reoxygenation. In SH-SY5Y human neuroblastoma cells, Clovamide (10-100 μM) protects cell death significantly with an EC50 value of 3.6 μM. Clovamide inhibits growth of three pathogens of cacao in the genus?Phytophthora, is a substrate for cacao polyphenol oxidase, and is a contributor to enzymatic browning. Clovamide inhibits proteinase and pectinase in vitro. Clovamide also enhances PPARγ expression.

Synonyms	trans-Clovamide, N-trans-Caffeoy-L-dopa
Molecular Weight	359.33
Formula	C18H17NO7
CAS No.	53755-02-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (347.87 mM), Sonification and heating to 60℃ are recommended.

References and Literature

1. Naike Ye, et al. Antioxidant studies by hydrodynamic voltammetry and DFT, quantitative analyses by HPLC-DAD of clovamide, a natural phenolic compound found in Theobroma Cacao L. beans. Food Chem. 2021 Mar 30;341(Pt 2):128260. 2. S Fallarini, et al. Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. Br J Pharmacol. 2009 Jul;157(6):1072-84.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Pyroptosis Compound Library Anti-Viral Compound Library Anti-Infection Compound Library Anti-Obesity Compound Library Oxidation-Reduction Compound Library Natural Product Library Cuproptosis Compound Library Apoptosis Compound Library Anti-Parkinson's Disease Compound Library

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Keywords

Clovamide 53755-02-5 Apoptosis Immunology/Inflammation Microbiology/Virology Influenza Virus Antibacterial ROS anti-inflammatory Reactive Oxygen Species Bacterial phenolic neuroprotective Inhibitor antioxidant inhibit trans-Clovamide N-trans-Caffeoy-L-dopa inhibitor

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