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Compound 3344 hydrochloride

Catalog No. T9184L   CAS T9184L
Synonyms: 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base), Compound 3344 hydrochloride (2368246-78-8 free base)

Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.

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Compound 3344 hydrochloride Chemical Structure
Compound 3344 hydrochloride, CAS T9184L
Pack Size Availability Price/USD Quantity
1 mg In stock $ 146.00
5 mg In stock $ 298.00
10 mg In stock $ 448.00
25 mg In stock $ 739.00
50 mg In stock $ 987.00
100 mg In stock $ 1,380.00
1 mL * 10 mM (in DMSO) In stock $ 353.00
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Purity: 99.89%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
In vitro In vitro competition studies of 3344 hydrochloride binding to KRAS-G12V in waterLOGSY NMR show the anti-RAS scFv inhibits 3344 hydrochloride binding to KRAS. In view of the in vitro inhibition by the anti-RAS scFv of 3344 hydrochloride binding to RASand because the iDAb RAS interferes with BRET signal in cells, 3344 hydrochloride was used for validation of the BRET2 toolbox for RAS-effector PPI inhibitors.
Synonyms 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base), Compound 3344 hydrochloride (2368246-78-8 free base)
Molecular Weight 426.94
Formula C24H27ClN2O3
CAS No. T9184L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (140.53 mM)

TargetMolReferences and Literature

1. Nicolas B , Abimael C M , Carole J B , et al. BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions[J]. Elife, 2018, 7:e37122-.

Related compound libraries

This product is contained In the following compound libraries:
HIF-1 Signaling Pathway Compound Library Anti-Ovarian Cancer Compound Library Anti-Cancer Compound Library Inhibitor Library MAPK Inhibitor Library Anti-Pancreatic Cancer Compound Library Anti-Liver Cancer Compound Library Kinase Inhibitor Library NO PAINS Compound Library Reprogramming Compound Library

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ARS-1630 CASIN Ras Inhibitory Peptide acetate KRas G12C inhibitor 3 KRAS G12C inhibitor 19 BAY-293 (S)-AMG-510 1588-A4

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Keywords

Compound 3344 hydrochloride T9184L GPCR/G Protein MAPK Ras 2368246-78-8 free base Compound 3344 Hydrochloride 2368246-78-8 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base) Compound 3344 hydrochloride (2368246-78-8 free base) inhibitor inhibit

 

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