Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 146.00 | |
5 mg | In stock | $ 298.00 | |
10 mg | In stock | $ 448.00 | |
25 mg | In stock | $ 739.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,380.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 353.00 |
Description | Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nm. |
In vitro | In vitro competition studies of 3344 hydrochloride binding to KRAS-G12V in waterLOGSY NMR show the anti-RAS scFv inhibits 3344 hydrochloride binding to KRAS. In view of the in vitro inhibition by the anti-RAS scFv of 3344 hydrochloride binding to RASand because the iDAb RAS interferes with BRET signal in cells, 3344 hydrochloride was used for validation of the BRET2 toolbox for RAS-effector PPI inhibitors. |
Synonyms | 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base), Compound 3344 hydrochloride (2368246-78-8 free base) |
Molecular Weight | 426.94 |
Formula | C24H27ClN2O3 |
CAS No. | T9184L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (140.53 mM)
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Compound 3344 hydrochloride T9184L GPCR/G Protein MAPK Ras 2368246-78-8 free base Compound 3344 Hydrochloride 2368246-78-8 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base) Compound 3344 hydrochloride (2368246-78-8 free base) inhibitor inhibit