Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | Inquiry | |
25 mg | In stock | $ 43.00 | |
50 mg | In stock | $ 61.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease. |
Targets&IC50 | TgPrxII:23 µM (IC50) |
Molecular Weight | 347.99 |
Formula | C10H8Br2N2O2 |
CAS No. | 18080-67-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 14.29 mg/mL (41.06 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Conoidin A 18080-67-6 Microbiology/Virology Parasite antioxidative antioxidant heart disease Inhibitor Peroxiredoxin II hyperperoxidation ischaemic inhibit neuroprotective inhibitor