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Cucurbitacin B

Catalog No. T3404 CAS 6199-67-3

Synonyms: Cuc B, DATISCACIN, Amarine

Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.

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Cucurbitacin B, CAS 6199-67-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 167.00
25 mg	In stock	$ 337.00
50 mg	In stock	$ 597.00
100 mg	In stock	$ 798.00
1 mL * 10 mM (in DMSO)	In stock	$ 119.00

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Purity: 99.33%

Purity: 99.08%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.
In vitro	Cucurbitacin B inhibits the growth of 5 GBM cell lines: U87, U118, U343, U373 and T98 g by affecting the cytoskeleton and the JNK pathway, with ED50 ranged from 5 nM to 100 nM. Cucurbitacin B also causes cell cycle arrest at the G2/M phase, decreases cell migration and induces apoptosis of GBM cells. [1] In human breast cancer cell lines, Cucurbitacin B also inhibits cell growth with ED50 varied from 30.3 nM to 418 nM, and rapidly induces cytoskeletal disruption. [2] In addition, Cucurbitacin B possesses immunomodulatory and anti-inflammatory effects, depending on the induction of heme oxygenase-1 expression via Nrf2 activation. [3]
In vivo	In nude mice bearing MDA-MB-231 tumors, Cucurbitacin B (1 mg/kg, i.p.) inhibits tumor growth by 55 %, and causes lower serum glucose levels. [2]
Cell Research	For proliferation measurements, the cells are placed into 96 well plates, and cell growth is measured at various times by MTT assay according to the protocol.(Only for Reference)
Source	Natural Products > Cucurbitaceae > Lagenaria

Synonyms	Cuc B, DATISCACIN, Amarine
Molecular Weight	558.7
Formula	C32H46O8
CAS No.	6199-67-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 91 mg/mL(162.9 mM)

Chloroform, Dichloromethane, Ethyl Acetate: Soluble

Ethanol: 50 mg/mL (89.49 mM)

References and Literature

1. Yin D, et al. Int J Cancer. 2008, 123(6), 1364-1375. 2. Wakimoto N, et al. Cancer Sci. 2008, 99(9), 1793-1797. 3. Kim M. et al. Immunopharmacol Immunotoxicol. 2015, 37(5), 473-480.

Citations

1. Ge J B, Jiang B, Shi T S, et al.Cucurbitacin B exerts significant antidepressant-like effects in a chronic unpredictable mild stress model of depression: Involvement of the hippocampal BDNF-TrkB system.International Journal of Neuropsychopharmacology.2023: pyad052.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Traditional Chinese Medicine Monomer Library Anti-Fibrosis Compound Library Cancer Cell Differentiation Compound Library Anti-Liver Cancer Compound Library Oxidation-Reduction Compound Library Anti-Colorectal Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-Ovarian Cancer Compound Library

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Keywords

Cucurbitacin B 6199-67-3 Angiogenesis Apoptosis Autophagy Chromatin/Epigenetic Cytoskeletal Signaling JAK/STAT signaling Metabolism PI3K/Akt/mTOR signaling Stem Cells PTEN Integrin Endogenous Metabolite HIF STAT Inhibitor Cuc B inhibit DATISCACIN Amarine inhibitor

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