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Cucurbitacin B

Catalog No. T3404   CAS 6199-67-3
Synonyms: Inhibitor, Integrin, Apoptosis, inhibit, Cucurbitacin B, Endogenous Metabolite, Amarine, Autophagy, Cuc B, DATISCACIN

Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.

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Cucurbitacin B, CAS 6199-67-3
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.
In vitro Cucurbitacin B inhibits the growth of 5 GBM cell lines: U87, U118, U343, U373 and T98 g by affecting the cytoskeleton and the JNK pathway, with ED50 ranged from 5 nM to 100 nM. Cucurbitacin B also causes cell cycle arrest at the G2/M phase, decreases cell migration and induces apoptosis of GBM cells. [1] In human breast cancer cell lines, Cucurbitacin B also inhibits cell growth with ED50 varied from 30.3 nM to 418 nM, and rapidly induces cytoskeletal disruption. [2] In addition, Cucurbitacin B possesses immunomodulatory and anti-inflammatory effects, depending on the induction of heme oxygenase-1 expression via Nrf2 activation. [3]
In vivo In nude mice bearing MDA-MB-231 tumors, Cucurbitacin B (1 mg/kg, i.p.) inhibits tumor growth by 55 %, and causes lower serum glucose levels. [2]
Cell Research For proliferation measurements, the cells are placed into 96 well plates, and cell growth is measured at various times by MTT assay according to the protocol.(Only for Reference)
Synonyms Inhibitor, Integrin, Apoptosis, inhibit, Cucurbitacin B, Endogenous Metabolite, Amarine, Autophagy, Cuc B, DATISCACIN
Molecular Weight 558.712
Formula C32H46O8
CAS No. 6199-67-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 91 mg/mL(162.9 mM)

Chloroform, Dichloromethane, Ethyl Acetate: Soluble

Ethanol: 50 mg/mL (89.49 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Yin D, et al. Int J Cancer. 2008, 123(6), 1364-1375. 2. Wakimoto N, et al. Cancer Sci. 2008, 99(9), 1793-1797. 3. Kim M. et al. Immunopharmacol Immunotoxicol. 2015, 37(5), 473-480.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Autophagy Compound Library Terpene Natural Product Library Anti-Lung Cancer Compound Library HIF-1 Signaling Pathway Compound Library Phosphatase Inhibitor Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Traditional Chinese Medicine Monomer Library Anti-Pancreatic Cancer Compound Library

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