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Cyclic ADP-​ribose

Catalog No. T19253   CAS 119340-53-3
Synonyms: cADPR

Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release and extracellular influx caused by the opening of TRPM2 channels.

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Cyclic ADP-​ribose Chemical Structure
Cyclic ADP-​ribose, CAS 119340-53-3
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,520.00
50 mg 6-8 weeks $ 1,980.00
100 mg 6-8 weeks $ 2,500.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
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Description Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release and extracellular influx caused by the opening of TRPM2 channels.
In vitro In cells, cyclic ADP ribose (cADPR) plays an important role in the following processes: cell proliferation and differentiation, regulating for example the expansion of mesenchymal stem cells and hematopoietic progenitor cells, neuronal differentiation of PC12 cells and mouse embryonic stem cells Cardiomyocyte differentiation.
In vivo In mammals, cyclic ADP-ribose (cADPR) plays an important role in the following processes: inflammation and immune response, including neutrophil chemotaxis and T cell activation; smooth muscle cell contraction in arteries and bronchial tubes, involved Hypoxic pulmonary vasoconstriction and the pathogenesis of inflammation / allergic airway diseases; myometrial contractility, which ultimately helps delivery; myocardial cell contraction in adult heart tissue, involved in angiotensin II and β-adrenaline Myocardial hypertrophy and arrhythmia caused by isoproterenol; endocrine and exocrine pancreatic secretion; social behavior of mice, including memory formation and spatial learning, are related to oxytocin secretion and may be related to niacin deficiency. In addition, cyclic ADP-ribose (cADPR) is involved in the activation and fertilization of eggs in seaweeds and sea urchins, early development of sea urchins, abscisic acid signaling in sponges and plants, cell fission in dinoflagellates, and pathogenicity of Toxoplasma gondii.
Synonyms cADPR
Molecular Weight 541.3
Formula C15H21N5O13P2
CAS No. 119340-53-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Ribeiro JM, et al. Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase. Sci Rep. 2018 Jan 18;8(1):1036.

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Keywords

Cyclic ADP-​ribose 119340-53-3 Membrane transporter/Ion channel Metabolism Calcium Channel Cyclic ADP​ribose Cyclic ADP-ribose Cyclic ADP ​ribose cADPR inhibitor inhibit

 

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