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Cyclizine dihydrochloride

Catalog No. T3037 CAS 5897-18-7

Synonyms: Cyclizine 2HCl, Marzine hydrochloride

Cyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness.

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Cyclizine dihydrochloride, CAS 5897-18-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Cyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness.

Synonyms	Cyclizine 2HCl, Marzine hydrochloride
Molecular Weight	339.3
Formula	C18H24Cl2N2
CAS No.	5897-18-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: <1 mg/mL

DMSO: 7 mg/mL (20.63 mM)

H2O: 62 mg/mL (182.7 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Vella-Brincat JW, et al. J Pain Symptom Manage. 2012 Mar;43(3):540-8.

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You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cyclizine dihydrochloride 5897-18-7 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor vomiting nausea Inhibitor selective Cyclizine Cyclizine 2HCl RAW 264.7 cells dizziness inhibit Marzine hydrochloride inhibitor

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