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Cycloguanil hydrochloride

Catalog No. T5420 CAS 152-53-4

Synonyms: Chloroguanide Triazine

Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, respectively).

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Cycloguanil hydrochloride Chemical Structure

Cycloguanil hydrochloride, CAS 152-53-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 36.00
2 mg	In stock	$ 51.00
5 mg	In stock	$ 77.00
10 mg	In stock	$ 126.00
25 mg	In stock	$ 207.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 549.00
1 mL * 10 mM (in DMSO)	In stock	$ 119.00

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Purity: 99.46%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Chloroguanide Triazine
Molecular Weight	288.18
Formula	C11H14ClN5.ClH
CAS No.	152-53-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (69.4 mM)

H2O: 5 mg/mL (17.35 mM)

References and Literature

1. Wright JD, et al. The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides. Br J Clin Pharmacol. 1995 Apr;39(4):441-4. 2. Yuvaniyama J, et al. Insights into antifolate resistance from malarial DHFR-TS structures. Nat Struct Biol. 2003 May;10(5):357-65.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Inhibitor Library NO PAINS Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max Anti-Infection Compound Library Bioactive Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cycloguanil hydrochloride 152-53-4 Metabolism Microbiology/Virology Drug Metabolite Parasite Cycloguanil Inhibitor Chloroguanide Triazine Cycloguanil Hydrochloride inhibit inhibitor

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