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D-Galactose

Catalog No. T0591 CAS 59-23-4

Synonyms: D-(+)-Galactose, D-Galactopyranose, Alpha-D-galactose

D-Galactose (Alpha-D-galactose) is an aldohexose that exists naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging.

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D-Galactose, CAS 59-23-4

Pack Size	Availability	Price/USD
200 mg	In stock	$ 30.00
500 mg	In stock	$ 42.00
1 g	In stock	$ 50.00
5 g	In stock	$ 68.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.84%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	D-Galactose (Alpha-D-galactose) is an aldohexose that exists naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging.
In vitro	Galactose is important for the survival and virulence of bacteria. Galactose is utilized by the Leloir pathway in Escherichia coli. Two anomers of d-galactose are used for different purposes, α-d-galactose as a carbon source and β-d-galactose for induction of UDP-galactose synthesis for biosynthetic glycosylation[1].
In vivo	Chronic D-galactose exposure induces neurodegeneration by enhancing caspase-mediated apoptosis and inhibiting neurogenesis and neuron migration in mice, as well as increasing oxidative damage. Moreover, D-galactose-induced toxicity in mice is a useful model for studying the mechanisms of neurodegeneration and neuroprotective drugs and agents[2]. D-galactose given by oral route leads to cognitive impairments in rats which are accompanied by oxidative damage. Cognitive impairments is observed in the open-field test in the 4th and 6th weeks after d-gal administration, as well as an impairment in spatial memory in the radial maze test after the 6th week of d-gal administration[3].

Synonyms	D-(+)-Galactose, D-Galactopyranose, Alpha-D-galactose
Molecular Weight	180.16
Formula	C6H12O6
CAS No.	59-23-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 66mg/mL（366.34mM）

DMSO: 55 mg/mL (305.28 mM)

References and Literature

1. Csiszovszki Z, et al. Structure and function of the D-galactose network in enterobacteria. MBio. 2011 Jun 28;2(4):e2020053-11. 2. Cui X, et al. Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidativedamage in mice: protective effects of R-alpha-lipoic acid. J Neurosci Res. 2006 Aug 15;84(3):647-54. 3. Budni J, et al. Oral administration of d-galactose induces cognitive impairments and oxidative damage in rats. Behav Brain Res. 2016 Apr 1;302:35-43.

Citations

1. Zhang H, Chen C, Liu Y, et al. NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules. Oxidative Medicine and Cellular Longevity. 2022 2. Zhang H, Cai J, Li C, et al.Wogonin inhibits latent HIV-1 reactivation by downregulating histone crotonylation.Phytomedicine.2023: 154855.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Traditional Chinese Medicine Monomer Library Tobacco Monomer Library Gut Microbial Metabolite Library Human Metabolite Library Inactive Ingredient Library Saccharide and Glycoside Natural Product Library Selected Plant-Sourced Compound Library Anti-Tumor Natural Product Library NO PAINS Compound Library

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Keywords

D-Galactose 59-23-4 Metabolism Endogenous Metabolite D-(+)-Galactose a-D-galactose inhibit Inhibitor D-Galactopyranose DGalactose α-D-galactose Alpha-D-galactose D Galactose inhibitor

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