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D-Kynurenine

Catalog No. T10938 CAS 13441-51-5

Synonyms: (R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid, ZINC901103

D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.

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D-Kynurenine, CAS 13441-51-5

Pack Size	Availability	Price/USD
25 mg	In stock	$ 48.00
50 mg	In stock	$ 82.00
100 mg	In stock	$ 132.00
200 mg	In stock	$ 195.00

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Purity: 97.08%

Biological Description

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Storage & Solubility Information

Description	D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.
In vitro	D-Kynurenine (10-100 µM) induces DER-enhancement and positively regulates the transfer of 95D cells, which is attenuated after siRNAAhr treatment in VIM and E-cadherin. D-Kynurenine (10 and 40 µM) significantly increases VIM expression and induces CYP1A1 upregulation. D-Kynurenine (10 µM) significantly attenuates the level of E-cadherin[4].

Synonyms	(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid, ZINC901103
Molecular Weight	208.21
Formula	C10H12N2O3
CAS No.	13441-51-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 5 mg/mL (24.01 mM), Sonification and heating to 60℃ are recommended.

References and Literature

1. Wang XD, et al. A method for the determination of D-kynurenine in biological tissues. Anal Bioanal Chem. 2013 Dec;405(30):9747-54. 2. Irukayama-Tomobe Y, et al. Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4. 3. Kozaki A, et al. Fluorimetric assay for D-amino acid oxidase activity in rat brain homogenate by using D-kynurenine as a substrate. Biosci Trends. 2012 Oct;6(5):241-7. 4. Duan Z, et al. Promoting epithelial-to-mesenchymal transition by D-kynurenine via activating aryl hydrocarbon receptor. Mol Cell Biochem. 2018 Nov;448(1-2):165-173.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Bioactive Compound Library Nuclear Receptor Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library

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Keywords

D-Kynurenine 13441-51-5 Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation Metabolism AhR GPR Endogenous Metabolite ZINC-901103 (R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid ZINC 901103 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid ZINC901103 inhibitor inhibit

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