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D8-MMAD

Catalog No. T10947 CAS T10947

Synonyms: Monomethylauristatin D D8, Demethyldolastatin 10 D8, Monomethyl Dolastatin 10 D8

D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer.

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D8-MMAD, CAS T10947

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 971.00
5 mg	Inquiry	$ 2,202.00
10 mg	Inquiry	$ 4,136.00
50 mg	Inquiry	Inquiry
100 mg	Inquiry	Inquiry
1 mL * 10 mM (in DMSO)	Inquiry	$ 3,546.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer.
In vitro	MMAD (monomethyl Dolastatin 10) is coupled through a stable oxime ligation process to produce several nearly uniform antibody-drug conjugates (ADC) with a pharmacodynamic ratio of approximately 2.0. The resulting conjugate showed good pharmacokinetic properties and had strong in vitro cytotoxic activity against HER2 + cancer cells. Compared with ADCs prepared by cysteine alkylation after reduction of natural interchain disulfide bonds, site-based unnatural amino acid-based ADCs have higher cytotoxicity in vitro.
In vivo	The resulting antibody-drug conjugate (ADC) showed complete tumor regression in rodents. Their toxicological characteristics in rats have also been improved.

Synonyms	Monomethylauristatin D D8, Demethyldolastatin 10 D8, Monomethyl Dolastatin 10 D8
Molecular Weight	779.11
Formula	C41H58D8N6O6S
CAS No.	T10947

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (128.35 mM)

References and Literature

1. Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

D8-MMAD T10947 Others Monomethylauristatin D D8 D-8-MMAD Demethyldolastatin 10 D8 D8MMAD Monomethyl Dolastatin 10 D8 D8 MMAD inhibitor inhibit

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