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DAPTA

Catalog No. T7624 CAS 106362-34-9

Synonyms: DAPTA(TFA), D-Ala-peptide T-amide, Adaptavir

DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

DAPTA, CAS 106362-34-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 47.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 155.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 443.00
100 mg	In stock	$ 639.00

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Purity: 100%

Biological Description

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Description	DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.
Targets&IC50	Gp120CM CM235/sCD4-CCR5:0.32 nM (IC50, in Cf2Th/synR5 cells), Gp120 BaL/sCD4-CCR5:55 pM (IC50, in Cf2Th/synR5 cells)
In vitro	D-Ala-peptide T-amide (DAPTA), or Peptide T, named for its high threonine content (ASTTTNYT), is a synthetic peptide comprised of eight amino acids (185-192) of the gp120 V2 region and functions as a viral entry inhibitor by targeting selectively CCR5.?The anti-HIV-1 activity of DAPTA was evaluated in M/M infected with R5 HIV-1 strains.?DAPTA at 10(-9) M inhibited HIV-1 replication in M/M by > 90%.?PCR analysis of viral cDNA in M/M showed that DAPTA blocks HIV entry and in this way prevents HIV-1 infection.?Moreover, DAPTA acts as a strong inhibitor and was more active than the non-peptidic CCR5 antagonist TAK-779 in inhibiting apoptosis (mediated by RS HIV-1 strains produced and released by infected M/M) on a neuroblastoma cell line[1]

Synonyms	DAPTA(TFA), D-Ala-peptide T-amide, Adaptavir
Molecular Weight	856.88
Formula	C35H56N10O15
CAS No.	106362-34-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10mM

References and Literature

1. Pollicita M , Ruff M R , Pert C B , et al. Profound Anti-HIV-1 Activity of DAPTA in Monocytes/macrophages and Inhibition of CCR5-mediated Apoptosis in Neuronal Cells[J]. Antiviral Chemistry and Chemotherapy, 2007, 18(5):285-295. 2. Michael R. Ruff, Maria Polianova, Quan-en Yang, Gifford S. Leoung, Francis W. Ruscetti, Candace B. Pert. Update on D-Ala-Peptide T-Amide (DAPTA): A Viral Entry Inhibitor that Blocks CCR5 Chemokine Receptors[J]. Current HIV Research, 2003, 1(1):p.51-67.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Peptide Compound Library Membrane Protein-targeted Compound Library Human Metabolite Library Anti-COVID-19 Compound Library Cytokine Inhibitor Library Clinical Compound Library NO PAINS Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DAPTA 106362-34-9 Immunology/Inflammation Microbiology/Virology Proteases/Proteasome HIV Protease CCR HIV DAPTA(TFA) CC chemokine receptor Human immunodeficiency virus D-Ala-peptide T-amide inhibit Adaptavir Inhibitor inhibitor

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