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DC-5163

Catalog No. T10966   CAS 897771-47-0

DC-5163 is a potent inhibitor of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with IC50 of 176.3 nM and Kd of 3.192 μM. DC-5163 selectively inhibits cancer cell proliferation and induces apoptosis, and partially inhibits the glycolysis pathway.

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DC-5163 Chemical Structure
DC-5163, CAS 897771-47-0
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,520.00
50 mg 6-8 weeks $ 1,980.00
100 mg 6-8 weeks $ 2,500.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description DC-5163 is a potent inhibitor of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with IC50 of 176.3 nM and Kd of 3.192 μM. DC-5163 selectively inhibits cancer cell proliferation and induces apoptosis, and partially inhibits the glycolysis pathway.
Targets&IC50 GAPDH:176.3 nM , GAPDH:(kd)3.192 μM
In vitro DC-5163 (100 μM; 48 hours; MDA-MB-231 cells) treatment can obviously induce apoptosis of MDA-MB-231 cells. DC-5163 inhibited the proliferation of MDA-MB-231 cells with an IC50 of 49.22 μM at 48 hours and 52.09 μM at 72 hours. Compared with the experimental control, DC-5163 also significantly reduced glucose uptake, lactic acid production and 18F-FDG uptake rate. After treatment with 25μM DC-5163 for 48 hours, it can inhibit the GAPDH activity of BT-549 cells, MCF7 cells, HCT116 cells, MDA-MB-231 cells and A549 cells.
Molecular Weight 361.89
Formula C18H20ClN3OS
CAS No. 897771-47-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 300 mg/mL (828.98 mM), sonification is recommended.

TargetMolReferences and Literature

1. Li T, et al. Discovery of novel glyceraldehyde-3-phosphate dehydrogenase inhibitor via docking-based virtual screening. Bioorg Chem. 2020 Mar;96:103620.

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Keywords

DC-5163 897771-47-0 Others DC5163 DC 5163 inhibitor inhibit

 

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