Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducing cancer cell proliferation and tumour growth.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 42.00 | |
5 mg | In stock | $ 68.00 | |
10 mg | In stock | $ 105.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 312.00 | |
100 mg | In stock | $ 468.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 75.00 |
Description | DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducing cancer cell proliferation and tumour growth. |
In vitro | DC_AC50 synergised with carboplatin in combination treatment of human and canine OSA cells to reduce cancer cell viability.?DC_AC50-treated cells were significantly less mitotically active, as demonstrated by decreased expression of phospho-histone H3 and cell cycle analysis.?DC_AC50 also potentiated carboplatin-induced apoptosis in OSA cells and decreased clonogenic survival.?Finally, DC_AC50 reduced the migratory ability of OSA cells.?These results justify further investigation into inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance. |
Molecular Weight | 424.26 |
Formula | C17H12BrF2N3OS |
CAS No. | 497061-48-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (58.93 mM)
You can also refer to dose conversion for different animals. More
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DC_AC50 497061-48-0 Apoptosis Others DC_AC-50 resistance osteosarcoma CCS copper chaperones Atox1 inhibit Chemotherapy Inhibitor inhibitor