Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | 10-14 weeks | $ 1,570.00 |
Description | DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM. |
Targets&IC50 | KDM1A/LSD1:84 nM |
In vitro | DDP-38003 inhibits KDM1A with an IC 50 of 84 nM. DDP-38003 is more active in reducing the colony-forming ability and in inducing the differentiation of THP-1 cells than the 1R, 2S analogue [1]. |
In vivo | DDP-38003 demonstrates effectiveness in vivo upon oral administration, leading to a 62% increase in survival rates in mouse leukemia models via KDM1A inhibition. It has a half-life of 8 hours. A notable dose-dependent enhancement in survival rates of mice treated with DDP-38003 is observed, with survival rates escalating by 35% and 62% at doses of 11.25 and 22.50 mg/kg, respectively, showcasing its potential as a cancer therapeutic [1]. |
Molecular Weight | 459.84 |
Formula | C21H29Cl3N4O |
CAS No. | T10983 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (217.47 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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